Detection of NDM-19, a novel variant of the New Delhi metallo-beta-lactamase with increased carbapenemase activity under zinc-limited conditions, in Switzerland

Mancini Stefano; Keller Peter M.; Greiner Michael; Bruderer Vera; Imkamp Frank

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Detection of NDM-19, a novel variant of the New Delhi metallo-beta-lactamase with increased carbapenemase activity under zinc-limited conditions, in Switzerland

机译：瑞士在瑞士，瑞士在限型条件下具有增加的碳结构酶活性的新德里金属 - β-内酰胺酶的新德里金属 - β-内酰胺酶的新改变。

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A novel New Delhi metallo-beta-lactamase (NDM) variant, NDM-19, was identified in a carbapenem-resistant E. coli strain isolated from a subcutaneous infection of a laparotomy scar from an Egyptian patient in a Swiss hospital. NDM-19 is a derivative of NDM-7, from which it differs by a single amino acid substitution (Ala233Val). Under zinc-limiting growth conditions, E. coli DH5 alpha transformants producing NDM-19 displayed reduced susceptibility towards expanded-spectrum cephalosporins and carbapenems as compared to transformants producing NDM-1 or NDM-7. (C) 2019 Elsevier Inc. All rights reserved.

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《Diagnostic microbiology and infectious disease》 |2019年第3期|共3页
作者
Mancini Stefano; Keller Peter M.; Greiner Michael; Bruderer Vera; Imkamp Frank;
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作者单位

Univ Zurich Inst Med Microbiol Zurich Switzerland;

Univ Zurich Inst Med Microbiol Zurich Switzerland;

Univ Zurich Univ Hosp Zurich Div Infect Dis Zurich Switzerland;

Univ Zurich Inst Med Microbiol Zurich Switzerland;

Univ Zurich Inst Med Microbiol Zurich Switzerland;

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正文语种 eng
中图分类传染病;
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1. Detection of NDM-19, a novel variant of the New Delhi metallo-beta-lactamase with increased carbapenemase activity under zinc-limited conditions, in Switzerland [J] . Mancini Stefano, Keller Peter M., Greiner Michael, Diagnostic microbiology and infectious disease . 2019,第3期

机译：瑞士在瑞士，瑞士在限型条件下具有增加的碳结构酶活性的新德里金属 - β-内酰胺酶的新德里金属 - β-内酰胺酶的新改变。
2. A Novel New Delhi Metallo-beta-Lactamase Variant, NDM-14, Isolated in a Chinese Hospital Possesses Increased Enzymatic Activity against Carbapenems [J] . Zou Dayang, Huang Yong, Zhao Xiangna, Antimicrobial agents and chemotherapy. . 2015,第4期

机译：在中国医院中分离出的新型新德里金属-β-内酰胺酶变异体NDM-14具有增加的针对碳青霉烯的酶活性。
3. Rapid Detection of New Delhi Metallo-β-Lactamase Gene and Variants Coding for Carbapenemases with Different Activities by Use of a PCR-Based In Vitro Protein Expression Method [J] . Li Huang, Xiumei Hu, Man Zhou, Journal of Clinical Microbiology . 2014,第6期

机译：使用基于PCR的体外蛋白表达方法快速检测新德里Metallo-β-内酰胺酶基因以及具有不同活性的碳青霉烯酶的变体编码
4. SEMI-AUTOMATED DETECTION OF TERRAIN ACTIVITY IN THE SWISS ALPINE PERIGLACIAL ENVIRONMENT FROM DINSAR SCENES [C] . Barboux Chloé, Delaloye Reynald, Lambiel Christophe, ESA living planet symposium . 2013

机译：DINSAR场景在瑞士阿尔卑斯山周缘环境中的土壤活动的半自动检测
5. Increasing physical activity in free-living conditions: An examination of the Kohler motivation gain effect. [D] . Irwin, Brandon C. 2012

机译：自由生活条件下增加体育锻炼：科勒动机获得效应的检验。
6. Rapid Detection of New Delhi Metallo-β-Lactamase Gene and Variants Coding for Carbapenemases with Different Activities by Use of a PCR-Based In Vitro Protein Expression Method [O] . Li Huang, Xiumei Hu, Man Zhou, 2014

机译：使用基于PCR的体外蛋白表达方法快速检测新德里Metallo-β-内酰胺酶基因以及具有不同活性的碳青霉烯酶的变体编码
7. Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing complex among patients in hospitals in Ha Noi, Viet Nam [O] . 2017

机译：越南河内的医院患者中新德里金属β-内酰胺酶1和其他碳青霉烯酶生产复合物的出现

Detection of NDM-19, a novel variant of the New Delhi metallo-beta-lactamase with increased carbapenemase activity under zinc-limited conditions, in Switzerland

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