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首页> 外文期刊>Alcohol >Decreased reward during acute alcohol withdrawal in rats selectively bred for low alcohol drinking.
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Decreased reward during acute alcohol withdrawal in rats selectively bred for low alcohol drinking.

机译：选择性戒酒以减少饮酒的大鼠急性戒断期间的奖励减少。

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We have previously hypothesized that increased sensitivity to the dysphoric-like or aversive effects of alcohol withdrawal following an initial exposure to alcohol might be associated with a genetic propensity to avoid alcohol. A decrease in brain reward function, as measured by an elevation in intracranial self-stimulation (ICSS) reward threshold, is one of the few methods available to model dysphoric-like or aversive effects of drug withdrawal in rats. We compared brain reward function during withdrawal following an initial exposure to alcohol in alcohol-naive rats selectively bred for high (HAD1 line) versus low (LAD1 line) voluntary alcohol consumption. Male HAD1 (n=5) and LAD1 (n=6) rats were implanted with unilateral electrodes in the medial forebrain bundle and trained to bar press for delivery of a 100 microA current that varied in frequency from 45 to 200 Hz. Responding for ICSS was generally stable within subjects across multiple experimental sessions on a given day and across several consecutive days prior to alcohol or water administration. ICSS responding was assessed in both rat lines prior to and at 12, 14, 16, 18, 20, and 24 h following a single intragastric infusion of alcohol (4.0 g/kg body weight) or water. Rats of the LAD1 line, but not those of the HAD1 line, exhibited a decrease in brain reward function as evidenced by a decrease in bar-press responding for ICSS and an increase in ICSS stimulation threshold during alcohol withdrawal. The results suggest that rats selectively bred for low alcohol drinking may experience dysphoric-like effects during withdrawal from an initial exposure to alcohol, while rats selectively bred for high alcohol drinking may not.
机译：我们以前曾假设，初次接触酒精后，对戒酒的烦躁不安或厌恶效应的敏感性增强可能与避免饮酒的遗传倾向有关。用颅内自我刺激（ICSS）奖励阈值的升高来衡量，大脑奖励功能的降低是可用于模拟大鼠戒断的烦躁不安或厌恶效应的几种方法之一。我们比较了初次饮酒的高酒精（HAD1品系）与低酒精（LAD1品系）自愿饮酒的初次接触酒精的大鼠在戒断后的大脑奖励功能。将雄性HAD1（n = 5）和LAD1（n = 6）大鼠在内侧前脑束中植入单侧电极，并训练其加压以传递100 microA电流，该电流的频率从45到200 Hz不等。在给定的一天和多次酒精或水给药之前的连续几天的多个实验阶段中，受试者对ICSS的反应通常是稳定的。在一次胃内输注酒精（4.0 g / kg体重）或水后以及在第12、14、16、18、20和24小时之前和之后的两个大鼠品系中评估了ICSS响应。 LAD1品系的大鼠而非HAD1品系的大鼠表现出大脑奖赏功能的降低，这是由戒酒对ICSS的响应减少以及在戒酒期间ICSS刺激阈值的升高所证明的。结果表明，选择性饮酒的大鼠在戒酒初期可能会出现烦躁不安的症状，而选择性饮酒的大鼠则可能没有这种感觉。

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