Phage-derived lysins as potential agents for eradicating biofilms and persisters

Sharma Umender; Vipra Aradhana; Channabasappa Shankaramurthy

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Phage-derived lysins as potential agents for eradicating biofilms and persisters

机译：噬菌体衍生的赖锡作为消除生物膜和持久性的潜在剂

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Bacterial biofilms are highly resistant to the action of antibiotics. Presence of persisters, phenotypically resistant populations of bacterial cells, is thought to contribute toward recalcitrance of biofilms. The phage-derived lysins, by virtue of their ability to cleave the peptidoglycan of bacterial cells in an enzymatic manner, have the unique ability to kill dormant cells. Several lysins have shown potent antibiofilm activity in vitro. The fact that lysins have shown better efficacy than conventional drugs in animal models of endocarditis and other infections involving biofilms suggests that the lysins can potentially be developed against difficult-to-treat bacterial infections.

机译：细菌生物膜对抗生素的作用具有高度抗性。存在持久性，细菌细胞的表型抗性群体，被认为有助于重新分析生物膜。凭借其能够以酶促方法切割细菌细胞的肽聚糖的能力，具有杀死休眠细胞的独特能力。几种裂解蛋白在体外显示有效的抗生素活性。裂解丝蛋白表明比心内膜炎的动物模型和涉及生物膜的其他感染的常规药物的效果更好的效果表明裂解蛋白可能会难以抵抗难以治疗的细菌感染。

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《Drug discovery today》 |2018年第4期|共9页
作者
Sharma Umender; Vipra Aradhana; Channabasappa Shankaramurthy;
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GangaGen Biotechnol Pvt Ltd 12 5th Cross Tumkur Rd Bangalore 560022 Karnataka India;

GangaGen Biotechnol Pvt Ltd 12 5th Cross Tumkur Rd Bangalore 560022 Karnataka India;

GangaGen Biotechnol Pvt Ltd 12 5th Cross Tumkur Rd Bangalore 560022 Karnataka India;

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正文语种 eng
中图分类药学;
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1. Phage-derived lysins as potential agents for eradicating biofilms and persisters [J] . Sharma Umender, Vipra Aradhana, Channabasappa Shankaramurthy Drug discovery today . 2018,第4期

机译：噬菌体衍生的赖锡作为消除生物膜和持久性的潜在剂
2. Phage-derived lysins as therapeutic agents against multidrug-resistant Enterococcus faecalis [J] . Gu Jingmin, Xi Hengyu, Cheng Mengjun, Journal of land use science . 2018,第1a3期

机译：噬菌体衍生的裂解蛋白作为治疗剂对抗多药肠球菌的治疗剂
3. Phage-derived lysins as therapeutic agents against multidrug-resistant Enterococcus faecalis [J] . Jingmin Gu, Hengyu Xi, Mengjun Cheng, Future microbiology . 2018,第3期

机译：噬菌体衍生的裂解蛋白作为治疗剂对抗多药肠球菌的治疗剂
4. (281e) The Role of Toxin/Antitoxin Systems in the General Stress Response, Biofilm Formation, and Persister Cell Formation [C] . Thomas K. Wood1, Xiaoxue Wang1, Younghoon Kim1, American Institute of Chemical Engineers annual meeting . 2010

机译：（281E）毒素/抗毒素系统在一般应力反应，生物膜形成和抗风细胞形成中的作用
5. Characterization and eradication of persisters in Candida albicans biofilms. [D] . La Fleur, Michael David. 2008

机译：表征和根除白色念珠菌生物膜中的持久性。
6. Tert-butyl benzoquinone: mechanism of biofilm eradication and potential for use as a topical antibiofilm agent [O] . N. Ooi, E. A. Eady, J. H. Cove, -1

机译：叔丁基苯醌：消除生物膜的机制以及用作局部抗生物膜剂的潜力
7. Biofilm/Persister/Stationary Phase Bacteria Cause More Severe Disease Than Log Phase Bacteria – II Infection with Persister Forms of Staphylococcus aureus Causes a Chronic Persistent Skin Infection with More Severe Lesion that Takes Longer to Heal and is not Eradicated by the Current Recommended Treatment in Mice [O] . Rebecca Yee, Yuting Yuan, Cory Brayton, 2018

机译：生物膜/抗风件/固定相细菌患者比对数细菌 - II感染更严重的疾病，葡萄球菌的葡萄球菌的形式导致慢性持续的皮肤感染具有更严重的病变，愈合需要更长的愈合，并且不会被小鼠的当前推荐治疗愈合更长时间。

Phage-derived lysins as potential agents for eradicating biofilms and persisters

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