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首页> 外文期刊>Drug delivery and translational research >Nanobiotechnological modules as molecular target tracker for the treatment and prevention of malaria: options and opportunity
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Nanobiotechnological modules as molecular target tracker for the treatment and prevention of malaria: options and opportunity

机译：作为分子目标跟踪器的纳米能力为治疗和预防疟疾：选择和机会

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Malaria is one of the major infectious diseases that remains a constant challenge to human being mainly due to the emergence of drug-resistant strains of parasite and also the availability of drugs, which are non-specific for their pharmacodynamic activity and known to be associated with multiple side effects. The disease has acquired endemic proportions in tropical countries where the hygienic conditions are not satisfactory while the environmental conditions favor the proliferation of parasite and its transmission, particularly through the female anopheles. It is obvious that to square up the problems, there is a need for designing and development of more effective drugs, which can combat the drug-resistant strains of the parasite. Molecular biology of the parasite and its homing into host cellular tropics provide multiple drug targets that could judiciously be considered for engineering and designing of new generation antimalarial drugs and also drug delivery systems. Though the recent reports document that against malaria parasite the vaccine could be developed, nevertheless, due to smart mutational change overs by the parasite, it is able to bypass the immune surveillance. The developed vaccine therefore failed to assure absolute protection against the malarial infection. In the conventional mode of treatment antimalarial drugs, the dose and dosage regimen that is followed at large crops up the contraindicative manifestations, and hence compromising the effective treatment. The emerging trends and new updates in contemporary biological sciences, material sciences, and drug delivery domain have enabled us with the availability of a multitude of mode and modules which could plunge upon the nanotechnology in particular to treat this challenging infection. The nanotechnology-based option may be tuned or customized as per the requirements to mark and target i.e. the infected RBCs, for targeted drug delivery.
机译：疟疾是主要的传染病之一，仍然是对人类持续挑战的主要原因是寄生虫耐药菌株的出现以及药物的可用性，这对于它们的药效学活动是非特异性的，并且已知与之相关多副作用。该疾病在热带国家中获得了流行性比例，卫生条件不令人满意，而环境条件有利于寄生虫的增殖及其传播，特别是通过女性粪便。显而易见的是，为了方便问题，需要设计和开发更有效的药物，可以打击寄生虫的耐药菌株。寄生虫的分子生物学及其归巢进入宿主的热带地带提供多种药物靶标，可以明智地考虑用于工程和设计新一代抗疟药和药物递送系统。虽然最近的报告文献患有针对疟疾寄生虫的疫苗可以开发，但由于寄生虫的智能突变变化，它能够绕过免疫监测。因此，发达的疫苗未能确保对疟疾感染的绝对保护。在常规的治疗方法中，抗疟疾药物，随后的剂量和剂量方案占据禁忌表现，因此损害了有效治疗。当代生物科学，物质科学和药物交付域中的新兴趋势和新的更新使我们能够在众多模式和模块的可用性方面使其可能会在纳米技术上暴跌，特别是治疗这种具有挑战性的感染。纳米技术的选项可以根据要求标记和靶向的要求进行调整或定制，用于受感染的RBC，用于靶向药物递送。

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