Assessment of Hedgehog Signaling Pathway Activation for Craniofacial Bone Regeneration in a Critical-Sized Rat Mandibular Defect

Miller Matthew Q.; McColl Logan F.; Arul Michael R.; Nip Jonathan; Madhu Vedavathi; Beck Gina; Mathur Kishan; Sahadeo Vashaana; Kerrigan Jason R.; Park Stephen S.; Christophel J. Jared; Dighe Abhijit S.; Kumbar Sangamesh G.; Cui Quanjun

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Assessment of Hedgehog Signaling Pathway Activation for Craniofacial Bone Regeneration in a Critical-Sized Rat Mandibular Defect

机译：刺猬信号通路激活颅面骨再生患者临界大鼠下颌缺损

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IMPORTANCE Osseous craniofacial defects are currently reconstructed with bone grafting, rigid fixation, free tissue transfer, and/or recombinant human bone morphogenetic protein 2. Although these treatment options often have good outcomes, they are associated with substantial morbidity, and many patients are not candidates for free tissue transfer.

机译：目前重建了重要的骨质颅面缺陷，骨移植，刚性固定，自由组织转移和/或重组人骨形态发生蛋白2。虽然这些治疗方案往往具有良好的结果，但它们与大量发病率有关，并且许多患者不是候选人免费组织转移。

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《JAMA facial plastic surgery》 |2019年第2期|共8页
作者
Miller Matthew Q.; McColl Logan F.; Arul Michael R.; Nip Jonathan; Madhu Vedavathi; Beck Gina; Mathur Kishan; Sahadeo Vashaana; Kerrigan Jason R.; Park Stephen S.; Christophel J. Jared; Dighe Abhijit S.; Kumbar Sangamesh G.; Cui Quanjun;
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Univ Virginia Dept Orthopaed Surg 545 Ray C Hunt Dr Med Off Bldg 2 Charlottesville VA 22908 USA;

Univ Virginia Dept Orthopaed Surg 545 Ray C Hunt Dr Med Off Bldg 2 Charlottesville VA 22908 USA;

Univ Connecticut Dept Orthopaed Surg 263 Farmington Ave Farmington CT 06030 USA;

Univ Connecticut Dept Orthopaed Surg 263 Farmington Ave Farmington CT 06030 USA;

Univ Virginia Dept Orthopaed Surg 545 Ray C Hunt Dr Med Off Bldg 2 Charlottesville VA 22908 USA;

Univ Virginia Dept Orthopaed Surg 545 Ray C Hunt Dr Med Off Bldg 2 Charlottesville VA 22908 USA;

Univ Virginia Dept Mech &

Aerosp Engn Ctr Appl Biomech Charlottesville VA USA;

Univ Virginia Dept Orthopaed Surg 545 Ray C Hunt Dr Med Off Bldg 2 Charlottesville VA 22908 USA;

Univ Virginia Dept Orthopaed Surg 545 Ray C Hunt Dr Med Off Bldg 2 Charlottesville VA 22908 USA;

Univ Virginia Dept Otolaryngol Charlottesville VA USA;

Univ Virginia Dept Otolaryngol Charlottesville VA USA;

Univ Virginia Dept Orthopaed Surg 545 Ray C Hunt Dr Med Off Bldg 2 Charlottesville VA 22908 USA;

Univ Connecticut Dept Orthopaed Surg 263 Farmington Ave Farmington CT 06030 USA;

Univ Virginia Dept Orthopaed Surg 545 Ray C Hunt Dr Med Off Bldg 2 Charlottesville VA 22908 USA;

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正文语种 eng
中图分类整形外科学（修复外科学）;
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专利

1. Assessment of Hedgehog Signaling Pathway Activation for Craniofacial Bone Regeneration in a Critical-Sized Rat Mandibular Defect [J] . Miller Matthew Q., McColl Logan F., Arul Michael R., JAMA facial plastic surgery . 2019,第2期

机译：刺猬信号通路激活颅面骨再生患者临界大鼠下颌缺损
2. Translating the role of osteogenic-angiogenic coupling in bone formation: Highly efficient chitosan-pDNA activated scaffolds can accelerate bone regeneration in critical-sized bone defects [J] . Rosanne M. Raftery, Irene Mencía Casta?o, Gang Chen, Biomaterials . 2017,第期

机译：翻译成骨血管生成偶联在骨形成中的作用：高效的壳聚糖-PDNA活化支架可以加速骨髓再生在临界大小的骨缺损中
3. Pretreatment of bone mesenchymal stem cells with miR181-c facilitates craniofacial defect reconstruction via activating AMPK-Mfn1 signaling pathways [J] . Longkun Fan, Jingxian Wang, Chao Ma Journal of receptor and signal transduction research . 2019,第1a6期

机译：用miR181-C的骨髓间充质干细胞的预处理通过激活AMPK-MFN1信号传导途径促进颅面缺陷重建
4. Bone Morphogenetic Protein-2 Incorporated Beta-Tricalcium Phosphate Enhanced Bone Regeneration of Critical-Sized Bone Defects in Rats [C] . Lingfei Wei, Gang Wu, Liquan Deng Symposium and Annual Meeting of the International Society for Ceramics in Medicine . 2018

机译：骨形态发生蛋白-2掺入β-磷酸钙，提高大鼠临界骨缺损的骨质再生
5. Two Stage Repair of Composite Craniofacial Defects with Antibiotic Releasing Porous Poly(methyl methacrylate) Space Maintainers and Bone Regeneration. [D] . Spicer, Patrick. 2013

机译：抗生素释放多孔聚甲基丙烯酸甲酯空间保持剂和骨再生的复合颅面缺损两阶段修复。
6. Octacalcium phosphate/gelatin composite facilitates bone regeneration of critical-sized mandibular defects in rats: A quantitative study [O] . Fereydoon Sargolzaei-Aval, Eshagh Ali Saberi, Mohammad Reza Arab, 2019

机译：磷酸八钙/明胶复合材料促进大鼠下颌骨临界大小的骨再生：一项定量研究
7. Assessment of Hedgehog Signaling Pathway Activation for Craniofacial Bone Regeneration in a Critical-Sized Rat Mandibular Defect [O] . Matthew Q. Miller, Logan F. McColl, Michael R. Arul, 2019

机译：刺猬信号通路激活对临界大鼠下颌缺损的颅面骨再生的评估

Assessment of Hedgehog Signaling Pathway Activation for Craniofacial Bone Regeneration in a Critical-Sized Rat Mandibular Defect

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