...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Analytical Toxicology >The Application of a Single-Column GC-MS-MS Method for the Rapid Analysis of Chemical Warfare Agents and Breakdown Products
【24h】

The Application of a Single-Column GC-MS-MS Method for the Rapid Analysis of Chemical Warfare Agents and Breakdown Products

机译：单柱GC-MS-MS方法的应用在化学造成药物的快速分析和击穿产品

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The development of one comprehensive gas chromatographic-triple quadrupole mass spectrometric (GC-MS-MS) method for the analysis of nerve agents and their breakdown products can pose a challenge due to significant differences in analyte volatility. Nerve agent breakdown products typically have a low volatility, requiring a derivatization step prior to analysis by gas chromatography (GC). However, nerve agent parent compounds are generally more volatile, which eliminates the need for derivatization and allows for direct analysis. Therefore, the analysis of these analytes is typically performed using separate analytical methods. This may require the use of multiple columns composed of different stationary phases to ensure the most efficient separation. With the wide selection of GC columns and derivatizing agents, it is potentially possible to develop a single-column/analytical method that is suitable for the detection of nerve agents and their breakdown products. We evaluated six nerve agents (tabun, sarin, soman, cyclosarin, VX and Russian VX) and the six corresponding breakdown products (EDPA, IMPA, PMPA, CMPA EMPA and MMPA). Chromatographic separation and multiple-reaction mode electron ionization detection of the nerve agents and silylated breakdown product derivatives were performed using an Agilent 7890 A gas chromatography (GC) equipped with a mid-polarity column, coupled to a 7000 triple quadrupole mass spectrometry system. A fast (12.5 min), highly sensitive (picogram) and selective method was achieved. The feasibility of this method for nerve agent and breakdown product detection in real samples was demonstrated using nerve agent-spiked human plasma at various exposure times (3 min, 1 h and 24 h). Five of the six nerve agents and all six breakdown products were successfully detected. This robust method has utility as a rapid screening tool to identify a specific nerve agent in a potential exposure event by simultaneous detection of the parent and or its corresponding breakdown product in plasma.
机译：一种综合气相色谱 - 三倍四极杆质谱（GC-MS-MS）用于分析神经剂的综合气相色谱和其击穿产品的开发可能由于分析物挥发性的显着差异而造成挑战。神经剂击穿产品通常具有低挥发性，在通过气相色谱（GC）分析之前需要衍生化步骤。然而，神经剂母体化合物通常更挥发，这消除了衍生化的需要并允许直接分析。因此，通常使用单独的分析方法进行这些分析物的分析。这可能需要使用由不同的固定阶段组成的多个列以确保最有效的分离。随着广泛的GC柱和衍生剂的选择，可能开发一种适用于检测神经剂及其击穿产品的单柱/分析方法。我们评估了六个神经剂（Tabun，Sarin，Soman，Cyclosarin，VX和俄语VX）以及六种相应的击穿产品（EDPA，IMPA，PMPA，CMPA EMPA和MMPA）。使用具有中间极性柱的Agilent 7890 A气相色谱（GC）进行色谱分离和多反应模式电子电离检测，并使用配备有中间极性柱的气相色谱（GC），耦合到7000三极高压质谱系统。实现了快速（12.5分钟），高度敏感的（皮科）和选择性方法。使用神经剂 - 尖刺的人血浆在各种暴露时间（3分钟，1小时和24小时），证明了这种神经剂和击穿产品检测方法的可行性。成功地检测到六个神经剂中的五种和所有六种崩溃产品。这种稳健的方法通过同时检测父母和等离子体中的相应的击穿产品，具有快速筛选工具作为快速筛选工具，以鉴定潜在的暴露事件中的特定神经剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号