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首页> 外文期刊>Journal of applied toxicology >In vivo In vivo noninvasive analysis of graphene nanomaterial pharmacokinetics using photoacoustic flow cytometry
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In vivo In vivo noninvasive analysis of graphene nanomaterial pharmacokinetics using photoacoustic flow cytometry

机译:磷烯纳米材料药代动力学使用光声流动细胞学体内体内体内inVivo

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摘要

Abstract Graphene‐based nanomaterials (GBNs) are quickly revolutionizing modern electronics, energy generation and storage, clothing and biomedical devices. Due to GBN's variety of physical and chemical parameters that define their toxicity and their aggregation in suspension, interpreting its toxicology without accurate information on graphene's distribution and behavior in live organisms is challenging. In this work, we present a laser‐based optical detection methodology for noninvasive detection and pharmacokinetics analysis of GBNs directly in blood flow in mice using in vivo photoacoustic (PA) flow cytometry (PAFC). PAFC provides unique insight on how chemical modifications of GBNs affect their distribution in blood circulation and how quickly they are eliminated from the flow. Overall, PAFC provided unique data crucial for understanding GBN toxicity through real‐time detection of GBNs using their intrinsic light absorption contrast. Copyright ? 2017 John Wiley & Sons, Ltd.
机译:摘要基于石墨烯的纳米材料(GBNS)迅速彻底改变现代电子,能源生成和储存,服装和生物医学设备。由于GBN的各种物理和化学参数定义了它们的毒性和它们在悬浮中的聚集,解释其毒理学而无需准确的石墨烯的分布和活生物体行为是具有挑战性的。在这项工作中,我们介绍了一种基于激光的光学检测方法,用于在使用体内光声(PA)流式细胞术(PAFC)中直接在小鼠血流中的GBNS的非侵入性检测和药代动力学分析。 PAFC提供了独特的洞察,就GBNS的化学修改如何影响其在血液循环中的分布以及它们从流动中消除的速度。总的来说,PAFC通过使用其固有的光吸收对比度来实现GBN毒性的独特数据至关重要。版权? 2017年John Wiley& SONS,LTD.

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