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首页> 外文期刊>Journal of applied toxicology >The toxic potential of a fourth‐generation E‐cigarette on human lung cell lines and tissue explants
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The toxic potential of a fourth‐generation E‐cigarette on human lung cell lines and tissue explants

机译：第四代电子烟对人肺细胞系和组织外植体的毒性潜力

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Abstract The use of electronic cigarettes (Ecigs) is rapidly increasing. The latest generation of Ecigs is highly customizable, allowing for high heating coil temperatures. The aim of this study was to assess the toxic potential of a fourthgeneration Ecig. Aerosols generated from Eliquid with (24爉g/mL) and without nicotine, using a fourthgeneration Ecig, were chemically analysed and compared with cigarette smoke (K3R4F). Human lung epithelial cell lines and distal lung tissue explants were exposed to Ecig vapour extract (EVE) and cigarette smoke extract for 24爃ours and assessed for viability, inflammation, oxidative stress and genotoxicity. Ecig aerosols contained measurable levels of volatile organic compounds, aldehydes and polycyclic aromatic hydrocarbons, in general, to a much lesser extent than cigarette smoke. Higher levels of certain carbonyls, e.g. formaldehyde, were detected in the Ecig aerosols. EVEs decreased cell viability of BEAS2B cells, whereas little effect was seen in A549 cells and distal lung tissue. The nicotinecontaining EVE caused a greater decrease in cell viability and significant increase in DNA damage than the nicotinefree EVE. Increased cytotoxicity, reactive oxygen species production and genotoxicity were seen with cells and tissue exposed to cigarette smoke extract compared with EVEs. Although Ecig aerosols were less toxic than cigarette smoke, it was not benign. Moreover, the EVE containing nicotine was more toxic than the nicotinefree EVE. More research is needed on the short and longterm health effects of vaping and the usage of newly emerging Ecig devices to evaluate better the potential negative effects of Ecigs on human health.
机译：摘要使用电子烟（ECIGS）正在迅速增加。最新一代的生态物质是高度可定制的，允许高加热线圈温度。本研究的目的是评估第四天的毒性潜力。使用四根ECIG的（24÷g / ml）和不含尼古丁的烟雾产生的气溶胶，并与香烟烟雾（K3R4F）进行化学分析。人肺上皮细胞系和远端肺组织外植体暴露于ECIG蒸汽提取物（EVE）和卷烟烟雾提取物24‰，并评估活力，炎症，氧化应激和遗传毒性。 ECIG气溶胶通常含有可测量的挥发性有机化合物，醛和多环芳烃，总体而言比香烟烟雾更小。较高的某些羰基水平，例如，某些羰基。甲醛被检测在突发气溶胶中。 EVES降低了BEA2B细胞的细胞活力，而在A549细胞和远端肺组织中观察到几乎没有效果。烟火般的夏季夏季导致细胞活力的降低，并且DNA损伤的显着增加而不是尼古丁患者。与EVES相比，通过细胞和组织观察到细胞毒性增加，可反应性氧物种产生和遗留毒性。虽然ECIG气溶胶比香烟烟雾毒性较小，但这并不是良性的。此外，含有尼古丁的前夜比尼古丁紫外线更具毒性。需要更多的研究，对VAPING的短期和长期健康影响以及新兴的ECIG器件的使用来评估MECIGS对人类健康的潜在负面影响。

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