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Remifentanil impairs sperm motility reversibly in vitro

机译:Remifentanil在体外可逆地损害精子运动

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The study is to observe the effects of remifentanil on human sperm motility in vitro. After spermatozoa were washed and resuspended in Ham's F-10 medium, the washed human sperm suspensions were treated in vitro with different concentrations of remifentanil for 30 min. Sperm motility was assessed by computer-assisted sperm analysis at 5, 10, 15, and 30 min. Remifentanil significantly decreased (a + b) grade spermatozoa, between 5 and 10 min at the concentrations ranging from 0.1 to 100 μg L - 1 in a dose-dependent manner and effects no significant difference at 15 and 30 min as compared with control groups. The results suggest that there is indication that this drug has short-term effect on sperm motility.
机译:该研究是观察Remifentanil对体外人体精子运动的影响。 将精子洗涤并重新悬浮在火腿的F-10培养基中,用不同浓度的雷芬丹尼尔在体外处理洗涤的人精子悬浮液30分钟。 通过在5,10,15和30分钟的计算机辅助精液分析评估精子活力。 雷芬丹尼显着降低(A + B)级精子,在浓度为0.1至100μgL - 1的浓度下,以剂量依赖性方式在5-10分钟之间,并且与对照组相比,在15和30分钟内没有显着差异。 结果表明,存在这种药物对精子运动的短期影响。

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