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首页> 外文期刊>Journal of biochemical and molecular toxicology >The prognostic value of T Lymphoma Invasion and Metastasis 1 (TIAM1) expression in oral squamous cell carcinoma
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The prognostic value of T Lymphoma Invasion and Metastasis 1 (TIAM1) expression in oral squamous cell carcinoma

机译：口腔鳞状细胞癌中T淋巴瘤侵袭和转移1（TIAM1）表达的预后价值

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摘要

Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm with high rate of lymph node metastasis and recurrence. The aim of this study is to evaluate the expression profile of T Lymphoma Invasion and Metastasis 1 (TIAM1) in OSCC and its correlation with clinical outcomes including lymph node metastasis and recurrence. Detection of TIAM1 expression in tumor samples from 56 OSCC patients and oral mucosa samples from 20 healthy people was performed by immunohistochemistry. Then immunostaining score of each patient was calculated. The results revealed that TIAM1 was aberrantly expressed in the OSCC group compared with the normal group. Furthermore, high expression of TIAM1 was significantly correlated with lymph node metastasis and the timing of recurrence. Assessment of TIAM1 expression might represent a valid tool in clinical practice for prediction of metastasis, recurrence, and prognosis of OSCC.
机译：摘要口腔鳞状细胞癌（OSCC）是最常见的恶性肿瘤，具有高淋巴结转移和复发率。 本研究的目的是评估OSCC中的T淋巴瘤侵袭和转移1（TIAM1）的表达谱及其与临床结果的相关性，包括淋巴结转移和复发。 通过免疫组织化学进行56例OSCC患者和口腔粘膜样品的肿瘤样本中TIAM1表达的检测。 然后计算每位患者的免疫染色得分。 结果表明，与正常组相比，TIAM1在OSCC组中异常表达。 此外，TIAM1的高表达与淋巴结转移和复发的时序显着相关。 Tiam1表达的评估可能代表临床实践中的有效工具，用于预测OSCC的转移，复发和预后。

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  • 作者

    Lin Lu; You Jingmin; Qian Yunmei; Han Ying; Xiong Haofeng; Zhu Tengfei; Xia Kun; Su Tong;

  • 作者单位

    Department of Stomatology Beijing YouAn HospitalCapital Medical UniversityBeijing 100069 People's;

    Department of StomatologyThe First People's Hospital of ChangdeChangde 415003 People's Republic of;

    Department of Oral and Maxillofacial Surgery Xiangya HospitalCentral‐South UniversityChangsha;

    Department of Oral and Maxillofacial Surgery Xiangya HospitalCentral‐South UniversityChangsha;

    Department of Oral and Maxillofacial Surgery Xiangya HospitalCentral‐South UniversityChangsha;

    State Key Laboratory of Medical GeneticsCentral South UniversityChangsha 410078 People's Republic;

    State Key Laboratory of Medical GeneticsCentral South UniversityChangsha 410078 People's Republic;

    Department of Oral and Maxillofacial Surgery Xiangya HospitalCentral‐South UniversityChangsha;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    metastasi; OSCC s; recurrence; TIAM1;

    机译：Metastasi;OSCC S;复发;TIAM1;

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