Effect of benzo[a] pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells

Chanyshev M. D.; Koval O. A.; Nushtaeva A. A.; Gulyaeva L. F.

首页> 外文期刊>Journal of biochemical and molecular toxicology >Effect of benzo[a] pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells

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Effect of benzo[a] pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells

机译：苯并[a]芘对miR-126，miR-190a及其靶基因Egfl7，Tp53inp1和phlpp1在初级子宫内膜细胞中的影响

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The main topic of this study was to investigate the effect of benzo[a]pyrene (BP) on microRNAs and their target genes expression levels in primary cell cultures from normal and malignant endometrial tissue. MicroRNA-126 (miR-126) and miR-190a were most sensitive to BP treatment. The treatment of both cultures with BP was accompanied by a decrease of miR-126 level and an increase of EGFL7 gene expression level. BP-induced upregulation of miR-190a was detected only in normal cells and it was accompanied with decrease of mRNA levels of TP53INP1 and PHLPP1 genes. Taking into account that BP promoted the proliferation of normal cells and amplified apoptosis of cancer cells, it is possible that miR-190a is involved in general cellular response to BP. The findings of this study indicate that miR-190a and its target genes may be involved in the regulation of cell fate under BP treatment.

机译：该研究的主要议题是研究来自正常和恶性子宫内膜组织的原代细胞培养物中苯并[A]芘（BP）对微小RORNA的影响及其靶基因表达水平。 MicroRNA-126（miR-126）和miR-190a对BP处理最敏感。将两种培养物的治疗伴有MIR-126水平的降低和EGFL7基因表达水平的增加。仅在正常细胞中检测到MIR-190A的BP诱导的上调，并伴随着TP53InP1和PHLPP1基因的mRNA水平的降低。考虑到BP促进正常细胞的增殖并扩增癌细胞的凋亡，MiR-190A可能参与GP的一般细胞反应。该研究的结果表明miR-190a及其靶基因可以参与细胞命运在BP处理下的调节。

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来源
《Journal of biochemical and molecular toxicology》 |2019年第6期|共6页
作者
Chanyshev M. D.; Koval O. A.; Nushtaeva A. A.; Gulyaeva L. F.;
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作者单位

Fed Res Ctr Fundamental &

Translat Med 2 Timakova St Novosibirsk 630117 Russia;

Novosibirsk State Univ Novosibirsk Russia;

Inst Chem Biol &

Fundamental Med Novosibirsk Russia;

Fed Res Ctr Fundamental &

Translat Med 2 Timakova St Novosibirsk 630117 Russia;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
benzoapyrene; endometrial primary cell culture; miR-126; miR-190a; target genes;

机译：苯并[a]芘;子宫内膜原细胞培养;miR-126;miR-190a;靶基因;

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1. Effect of benzo[a] pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells [J] . Chanyshev M. D., Koval O. A., Nushtaeva A. A., Journal of biochemical and molecular toxicology . 2019,第6期

机译：苯并[a]芘对miR-126，miR-190a及其靶基因Egfl7，Tp53inp1和phlpp1在初级子宫内膜细胞中的影响
2. The resveratrol analogue, 2,3′,4,5′-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene–DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene [J] . Tracey Einem Lindeman, Miriam C. Poirier Mutagenesis . 2011,第5期

机译：在暴露于苯并[a]′的MCF-7细胞中，白藜芦醇类似物2,3'，4,5'-四甲氧基sti不抑制CYP基因表达，酶活性和苯并[a] py-DNA加合物形成
3. The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo(a)pyrene-DNA adduct formation in MCF-7 cells exposed to benzo(a)pyrene. [J] . Einem Lindeman T, Poirier MC, Divi RL Mutagenesis . 2011,第5期

机译：白藜芦醇类似物2,3'，4,5'-四甲氧基sti，在暴露于苯并（a）MC的MCF-7细胞中，不抑制CYP基因表达，酶活性和苯并（a）--DNA加合物的形成。
4. EFFECTS OF BENZO[a]PYRENE, 2-BROMOPROPANE, PHENOL AND 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN ON PROINFLAMMATORY CYTOKINES GENE EXPRESSION BY MICE SPLEEN CELLS [C] . Ho-Jun Kim, Kyu-Shik Jeong, Bit-Na Kang, International symposium on halogenated environmental organic pollutants and persistent organic pollutants and POPs;DIOXIN;DIOXIN 2001;POPs . 2001

机译：苯并[a] Y，2-溴丙烷，苯酚和2,3,7,8-四氯二苯并偶氮-对-二恶英对小鼠脾细胞表达促炎细胞因子基因的影响
5. Benzo(a)pyrene-mediated effects on cellular adhesion and signal transduction pathways in endometrial cancer. [D] . McGarry, Michelle Ann. 2001

机译：苯并（a）-介导的对子宫内膜癌中细胞粘附和信号转导途径的影响。
6. ACTIVATION OF DIOXIN RESPONSE ELEMENT (DRE)-ASSOCIATED GENES BY BENZO(A)PYRENE 36-QUINONE AND BENZO(A)PYRENE 16-QUINONE IN MCF-10A HUMAN MAMMARY EPITHELIAL CELLS [O] . Scott W. Burchiel, Todd A. Thompson, Fredine T. Lauer, -1

机译：MCF-10A人乳腺上皮细胞中苯并（A）3 36-醌和苯并（A）116-醌对二恶英反应元素（DRE）相关基因的激活
7. Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice [O] . 2014

机译：苯并pyr诱导的目标和非目标器官中的DNA加合物和基因表达谱在小鼠中致癌
8. Metabolism and Macromolecular Binding of Benzo(A)Pyrene and Its Noncarcinogenic Isomer Benzo(E)Pyrene in Cell Culture [R] . Selkirk, J. K., MacLeod, M. C. 1978

机译：苯并（a）芘及其非致癌异构体苯并（E）芘在细胞培养中的代谢和大分子结合

Effect of benzo[a] pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells

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