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首页> 外文期刊>Journal of Biologically Active Products from Nature >Optimization of Cure u minimis Extraction for Evaluation Against Parkinson's Disease in Rats
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Optimization of Cure u minimis Extraction for Evaluation Against Parkinson's Disease in Rats

机译：治愈U最小提取评价对大鼠帕金森病评价的优化

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Curcuma longa (Family, Zingiberaceae) is rich in polyphenolic compounds; curcuminoids which is used in traditional medicine as antioxidant, anti-tumor, antimicrobial, anti-inflammatory, wound healing, and gastroprotective agents. The aim of the present work is to optimize curcuminoids extraction from C. longa rhizomes using different solvents and evaluate its efficacy in rotenone-induced Parkinson's disease in rats. The biological evaluation was done referring to Sinemet (levodopa) as dopaminergic drug and the newly ZM241385 as non-dopaminergic agent. The highest extraction yield was found in methanol (74 % w/w of defatted powder) and acetone (65 % w/w of defatted powder) extracts, while the highest curcuminoids content (566 mg/g extract) was foundin the ethyl acetate extract. High performance liquid chromatography (HPLC) analysis showed three major compounds; curcumin (68 %), demethoxycurcumin (19 %) and bisdemethoxycurcumin (11 %) of total curcuminoids. Rotenone induction caused disturbance in neurotransmitters, antioxidants, inflammatory and apoptotic markers, DNA fragmentation, adenosine A2A receptor gene expression, energy production markers and brain histological features. Treatments with ethyl acetate extract, Sinemet drug and ZM241385 enhanced the selected parameters by variable degrees. In conclusion, C. longa exerted anti-parkinsonism efficacy as compared to the classical Sinemet drug, while ZM241385 showed more therapeutic effect. As the plant extract improved DA and adenosine A geneexpression levels, this shed the light on its role as a therapeutic dopaminergic agent and therefore its mode of action must be studied in details.
机译：Curcuma Longa（家庭，Zingiberaceae）富含多酚化合物;姜黄素用于传统医学作为抗氧化剂，抗肿瘤，抗微生物，抗炎，伤口愈合和胃保护剂。本作目前的目的是利用不同溶剂优化来自C. Longa Rhizomes的姜黄素萃取，并评估其在大鼠中Rotenone诱导的帕金森病的疗效。将生物学评估作为多巴胺能药物和新ZM241385作为非多巴胺能试剂进行的生物学评价。在甲醇（74％w / w的缺陷粉末）和丙酮（65％w / w的脱脂粉末）提取物中发现了最高的提取产率，而最高姜黄素含量（566mg / g提取物）均氨氨基乙酯提取物。高效液相色谱（HPLC）分析显示出三种主要化合物;姜黄素（68％），去甲氧杂菌蛋白（19％）和双甲氧键菌蛋白（11％）的总姜黄素。 RotenOne诱导导致神经递质，抗氧化剂，炎症和凋亡标记，DNA碎片，腺苷A2A受体基因表达，能量产生标志物和脑组织学特征中的干扰。用乙酸乙酯提取物，SINEMET药物和ZM241385通过可变程度来增强所选参数的处理。总之，与古典中蜂药相比，C.Longa施加抗帕金森病有效性，而ZM241385显示出更多的治疗效果。随着植物提取物改善的DA和腺苷的碱性表达水平，这揭示了其作为治疗性多巴胺能试剂的作用，因此必须详细研究其作用方式。

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