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首页> 外文期刊>Journal of biomaterials applications >3D printing mesoporous bioactive glass/sodium alginate/gelatin sustained release scaffolds for bone repair
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3D printing mesoporous bioactive glass/sodium alginate/gelatin sustained release scaffolds for bone repair

机译：3D印刷中孔生物活性玻璃/藻酸钠/明胶持续释放支架用于骨骼修复

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摘要

Drug delivery and release are a major challenge fabricating bone tissue engineering. In this study, we fabricated new sustained release hydrogel scaffolds composited of mesoporous bioactive glass, sodium alginate and gelatin by a three-dimensional printing technique. Naringin and calcitonin gene-related peptide were used as drugs to prepare drug-loaded scaffolds by direct printing or surface absorption. The physicochemical properties of the scaffolds and the drug release profiles of the two drug-loading models were investigated. We also examined the biocompatibility of the scaffolds, as well as the effect of the released medium on the proliferation and osteogenic differentiation of human osteoblast-like MG-63 cell. The results showed that the scaffolds had a high porosity (approximately 80%) with an interconnected cubic pore structure, rough surface morphology, bioactivity and strong biocompatibility. Furthermore, the naringin or calcitonin gene-related peptide co-printed into the scaffold displayed a steady sustained release behaviour for up to 21 days without an initial burst release, while both naringin and calcitonin gene-related peptide absorbed onto the surface of the scaffold were completely released within two days. MG-63 cells cultured with the extraction containing released drugs displayed promoted cell proliferation and the expression of osteogenesis-related genes more effectively compared with the drug-free extractions. Therefore, these results demonstrate that the developed mesoporous bioactive glass/sodium alginate/gelatin sustained release scaffolds provide a potential application for bone tissue engineering.
机译：药物递送和释放是制造骨组织工程的主要挑战。在这项研究中，我们通过三维印刷技术制造了由介孔生物活性玻璃，藻酸钠和明胶的新的持续释放水凝胶支架。用直接印刷或表面吸收用作药物以制备药物负载的支架的药物和降钙素相关肽。研究了支架的物理化学性质和两种药物加载模型的药物释放谱。我们还研究了支架的生物相容性，以及释放介质对人成骨细胞样MG-63细胞增殖和骨质发生分化的影响。结果表明，支架具有高孔隙率（约80％），具有相互连接的立方体孔隙结构，粗糙表面形态，生物活性和强生物相容性。此外，共同蛋白或降钙素基因相关的肽在没有初始爆发释放的情况下，共同印刷到支架中呈现稳定的持续释放行为，持续21天，而Naringin和Calcitonin基因相关肽在支架表面上被吸收到支架上两天内完全发布。与含有释放的药物的萃取培养的Mg-63细胞显示出促进的细胞增殖和更有效地与无药物萃取相比的溶血性相关基因的表达。因此，这些结果表明，开发的介孔生物活性玻璃/藻酸钠/明胶持续释放支架提供了骨组织工程的潜在应用。

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    Wu Jingwen; Miao Guohou; Zheng Zhichao; Li Zhengmao; Ren Wen; Wu Caijuan; Li Yuanjing; Huang Zhu; Yang Lan; Guo Lvhua;

  • 作者单位

    Guangzhou Med Univ Stomatol Hosp Key Lab Oral Med Guangzhou Inst Oral Dis Huangsha Ave 39;

    Guangzhou Med Univ Stomatol Hosp Key Lab Oral Med Guangzhou Inst Oral Dis Huangsha Ave 39;

    Guangzhou Med Univ Stomatol Hosp Key Lab Oral Med Guangzhou Inst Oral Dis Huangsha Ave 39;

    Guangzhou Med Univ Stomatol Hosp Key Lab Oral Med Guangzhou Inst Oral Dis Huangsha Ave 39;

    Guangzhou Med Univ Stomatol Hosp Key Lab Oral Med Guangzhou Inst Oral Dis Huangsha Ave 39;

    Guangzhou Med Univ Stomatol Hosp Key Lab Oral Med Guangzhou Inst Oral Dis Huangsha Ave 39;

    Guangzhou Med Univ Stomatol Hosp Key Lab Oral Med Guangzhou Inst Oral Dis Huangsha Ave 39;

    Guangzhou Med Univ Stomatol Hosp Key Lab Oral Med Guangzhou Inst Oral Dis Huangsha Ave 39;

    Guangzhou Med Univ Stomatol Hosp Key Lab Oral Med Guangzhou Inst Oral Dis Huangsha Ave 39;

    Guangzhou Med Univ Stomatol Hosp Key Lab Oral Med Guangzhou Inst Oral Dis Huangsha Ave 39;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
  • 关键词

    Mesoporous bioactive glass/sodium alginate/gelatin; 3D printing; sustained release; bone repair;

    机译：中孔生物活性玻璃/藻酸钠/明胶;3D打印;持续释放;骨骼修复;

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