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首页> 外文期刊>Journal of Biomechanics >The role of transmembrane proteins on force transmission in skeletal muscle
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The role of transmembrane proteins on force transmission in skeletal muscle

机译：跨膜蛋白在骨骼肌中力传递中的作用

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摘要

Lateral transmission of force from myofibers laterally to the surrounding extracellular matrix (ECM) via the transmembrane proteins between them is impaired in old muscles. Changes in geometrical and mechanical properties of ECM of skeletal muscle do not fully explain the impaired lateral transmission with aging. The objective of this study was to determine the role of transmembrane proteins on force transmission in skeletal muscle. In this study, a 2D finite element model of single muscle fiber composed of myofiber, ECM, and the transmembrane proteins between them was developed to determine how changes in spatial density and mechanical properties of transmembrane proteins affect the force transmission in skeletal muscle. We found that force transmission and stress distribution are not affected by mechanical stiffness of the transmembrane proteins due to its non-linear stress-strain relationship. Results also showed that the muscle fiber with insufficient transmembrane proteins near the end of muscle fiber transmitted less force than that with more proteins does. Higher stress was observed in myofiber, ECM, and proteins in the muscle fiber with fewer proteins.
机译：通过跨膜蛋白横向于肌纤维的横向透射力通过它们之间的跨膜蛋白横向于周围的细胞外基质（ECM）。骨骼肌ECM的几何和力学性质的变化没有完全解释衰老的横向传播受损。本研究的目的是确定跨膜蛋白在骨骼肌中的力传递中的作用。在该研究中，开发了一种由肌纤维，ECM和跨膜蛋白组成的单肌纤维的2D有限元模型，以确定跨膜蛋白的空间密度和力学性能如何影响骨骼肌中的力传递。我们发现，由于其非线性应力 - 应变关系，跨膜蛋白的机械刚度不影响力传递和应力分布。结果还表明，肌纤维不足的跨膜蛋白附近的肌纤维末端的透射力小于较多的蛋白质。在肌纤维，ECM和肌纤维中的蛋白质中观察到更高的应力，蛋白质较少。

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