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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >The combined effect of thermal and chemotherapy on HeLa cells using magnetically actuated smart textured fibrous system
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The combined effect of thermal and chemotherapy on HeLa cells using magnetically actuated smart textured fibrous system

机译：热致动型智能纤维系统使用热化疗对HeLa细胞的综合作用

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Thermal therapy combined with chemotherapy is one of the advanced and efficient methods to eradicate cancer. In this work, we fabricated magnetically actuated smart textured (MAST) fibrous systems and studied their candidacy for cancer treatment. The polycaprolactone-Fe3O4 based MAST fibers were fabricated using electrospinning technique. These MAST fibrous systems contained carbogenic quantum dots as a tracking agent and doxorubicin hydrochloride anticancer drug. Additionally, as fabricated MAST fibrous systems were able to deliver anticancer drug and heat energy simultaneously to kill HeLa cells in a 10 min period in vitro. After treatment, the metabolic activity and morphology of HeLa cells were analyzed. In addition, the mechanism of cell death was studied using flow cytometry. Interestingly, the navigation of these systems in the fluid can be controlled with the application of gradient magnetic field. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 40-51, 2018.
机译：热疗法联合化疗是根除癌症的先进和有效的方法之一。在这项工作中，我们制造了磁力致动智能纹理（桅杆）纤维系统，并研究了他们的癌症治疗候选性。使用静电纺丝技术制造基于聚己内酯-FE3O4的桅杆纤维。这些肥大纤维系统含有肉毒型量子点作为跟踪剂和盐酸多柔比星抗癌药物。另外，由于制造的桅杆纤维体系能够同时递送抗癌药物和热能，以在体外10分钟内杀死HELA细胞。治疗后，分析了HeLa细胞的代谢活性和形态。此外，使用流式细胞术研究细胞死亡的机制。有趣的是，可以利用梯度磁场的应用来控制流体中这些系统的导航。 （c）2016年Wiley期刊，Inc。J生物保解员B部分B：苹果生物检索物，106B：40-51,2018。

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