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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Controlled synthesis of polyethylenimine coated gold nanoparticles: Application in glutathione sensing and nucleotide delivery
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Controlled synthesis of polyethylenimine coated gold nanoparticles: Application in glutathione sensing and nucleotide delivery

机译：聚乙烯醋醋涂层金纳米粒子的控制合成：在谷胱甘肽感应和核苷酸递送中的应用

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Abstract Synthesis of functional gold nanoparticles (AuNPs) justifying selectivity in biochemical interaction along with biocompatibility suited for in vivo biomedical applications has been a challenging issue. We report herein the role of polyethylenimine (PEI) in controlled synthesis of AuNPs under ambient conditions which has potentiality for sensing glutathione and selective interaction with DNA binding proteins facilitating endosomal escape for the nucleotide delivery. The choice of organic reducing agents like formaldehyde/acetaldehyde/acetyl acetone/tetrahydrofuran hydroperoxide and other similar compounds allow rapid conversion of PEI capped gold cations into AuNPs at room temperature thus controlling the functional ability of nanoparticles as a function of organic reducing agents. Both small and higher molecular weight PEI facilitates fast synthesis of AuNPs controlling cytotoxicity during in vivo biomedical applications. The AuNPs have been characterized by UV–Vis and transmission electron microscopy revealing excellent polycrystallinity and controlled nanogeometry. The cationic polymer coating enhances the electrocatalytic performances of nanoparticles. The typical biomedical application on glutathione (GSH) sensing based on peroxidase mimetic ability of as made AuNPs is studied. The as synthesized AuNPs are extreme salt and pH resistant and have potentiality for both homogeneous and heterogeneous biocatalysis. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1191–1199, 2017.
机译：摘要功能金纳米颗粒（AUNP）合成的合成生物化学相互作用以及适合体内生物医学应用的生物相容性一直是一个具有挑战性的问题。我们在本文中报告了聚乙烯亚胺（PEI）在环境条件下对αUNP的控制合成的作用，其具有感测谷胱甘肽和与DNA结合蛋白的选择性相互作用促进内体逸出的核苷酸递送。有机还原剂如甲醛/乙醛/乙酰丙酮/四氢呋喃氢氧化物和其他类似的化合物允许PEI封端的金阳离子在室温下快速转化为剖腹产，从而控制纳米颗粒的功能能力作为有机还原剂的函数。小型和较高的分子量PEI促进了在体内生物医学应用中的在体内生物医学应用期间控制细胞毒性的快速合成。 AUNPS的特征在于UV-VIS和透射电子显微镜，揭示了优异的多晶性和控制纳米齿轮术。阳离子聚合物涂层增强了纳米颗粒的电催化性能。研究了基于制造AUNPS的过氧化物酶模拟能力的谷胱甘肽（GSH）感测的典型生物医学应用。作为合成的AUNPS是极端盐和耐磷，对均匀和异质的生物分析具有潜力。还2016 Wiley期刊，Inc.J生物保解员B部分B：Appl Biomater，105B：1191-1199，2017。

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