The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report

Chung Jun Ku; Plitman Eric; Nakajima Shinichiro; Caravaggio Fernando; Shinagawa Shunichiro; Iwata Yusuke; Gerretsen Philip; Kim Julia; Takeuchi Hiroyoshi; Patel Raihaan; Chakravarty M. Mallar; Strafella Antonio; Graff-Guerrero Ariel

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The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report

机译：用疑似非阿尔茨海默病理论对轻度认知障碍临床术后临床轨迹的影响：简要报道

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The clinical and structural trajectories of suspected non-Alzheimer' pathology (SNAP) remain elusive due to its heterogeneous etiology. Baseline and longitudinal clinical (global cognition, daily functioning, symptoms of dementia, and learning memory) and hippocampal volume trajectories over two years were compared between patients with amnestic mild cognitive impairment (aMCI) with SNAP with reduced hippocampal volumes (SNAP+HIPPO) and aMCI patients with SNAP without reduced hippocampal volumes. SNAP+ HIPPO showed overall worse baseline cognitive functions. Longitudinally, SNAP+ HIPPO showed faster deterioration of clinical symptoms of dementia. Having both hippocampal atrophy and cortical hypometabolism without amyloid pathology may exacerbate symptoms of dementia in aMCI.

机译：由于其异质病因，疑似非阿尔茨海默病病理学（SNAP）的临床和结构轨迹仍然难以实现。在患有Amnestic轻度认知障碍（AMCI）的患者中，比较了两年多的纵向临床（全球认知，日常发作，痴呆，学习记忆症状）和海马体积轨迹，随着海马体积减少（SNAP + HIPPO）和 AMCI患者随着海马体积的减少而没有快速。 Snap + Hippo显示出总体更糟糕的基线认知功能。纵向，Snap + Hippo表现出痴呆症的临床症状的速度越来越快。在没有淀粉样蛋白病理学的情况下具有海马萎缩和皮质抑郁症状，可以加剧AMCI中痴呆症状的症状。

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来源
《Journal of Alzheimer's disease: JAD》 |2017年第2期|共7页
作者
Chung Jun Ku; Plitman Eric; Nakajima Shinichiro; Caravaggio Fernando; Shinagawa Shunichiro; Iwata Yusuke; Gerretsen Philip; Kim Julia; Takeuchi Hiroyoshi; Patel Raihaan; Chakravarty M. Mallar; Strafella Antonio; Graff-Guerrero Ariel;
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作者单位

Univ Toronto Inst Med Sci Fac Med Toronto ON Canada;

Univ Toronto Inst Med Sci Fac Med Toronto ON Canada;

Ctr Addict &

Mental Hlth Res Imaging Ctr Multimodal Imaging Grp 250 Coll St Toronto ON M5T 1R8;

Ctr Addict &

Mental Hlth Res Imaging Ctr Multimodal Imaging Grp 250 Coll St Toronto ON M5T 1R8;

Jikei Univ Sch Med Tokyo Japan;

Ctr Addict &

Mental Hlth Res Imaging Ctr Multimodal Imaging Grp 250 Coll St Toronto ON M5T 1R8;

Ctr Addict &

Mental Hlth Res Imaging Ctr Multimodal Imaging Grp 250 Coll St Toronto ON M5T 1R8;

Univ Toronto Inst Med Sci Fac Med Toronto ON Canada;

Univ Toronto Dept Psychiat Toronto ON Canada;

McGill Univ Douglas Mental Hlth Inst Cerebral Imaging Ctr Montreal PQ Canada;

McGill Univ Douglas Mental Hlth Inst Cerebral Imaging Ctr Montreal PQ Canada;

Univ Toronto Campbell Family Mental Hlth Res Inst Res Imaging Ctr Ctr Addict &

Mental Hlth;

Univ Toronto Inst Med Sci Fac Med Toronto ON Canada;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Functional decline; hippocampus; mild cognitive impairment; suspected non-Alzheimer's pathology;

机译：功能下降;海马;轻度认知障碍;怀疑非阿尔茨海默氏病病;

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专利

1. The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report [J] . Chung Jun Ku, Plitman Eric, Nakajima Shinichiro, Journal of Alzheimer's disease: JAD . 2017,第2期

机译：用疑似非阿尔茨海默病理论对轻度认知障碍临床术后临床轨迹的影响：简要报道
2. Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: Comparison with amyloid-positive mild cognitive impairment [J] . YeB.S., SeoS.W., KimC.H., Neurobiology of Aging: Experimental and Clinical Research . 2014,第2期

机译：淀粉样蛋白阴性轻度认知障碍的海马和皮质萎缩：与淀粉样蛋白阳性轻度认知障碍的比较
3. Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study [J] . Burnham Samantha C., Bourgeat Pierrick, Dore Vincent, Lancet Neurology . 2016,第10期

机译：具有可疑的非阿尔茨海默氏病病理生理学（SNAP）或阿尔茨海默氏病病理学的认知健康老年人的临床和认知轨迹：一项纵向研究
4. Increasing Power to Predict Mild Cognitive Impairment Conversion to Alzheimer's Disease Using Hippocampal Atrophy Rate and Statistical Shape Models [C] . Kelvin K. Leung, Kai-Kai Shen, Josephine Barnes, International conference on medical image computing and computer-assisted intervention;MICCAI 2010 . 2010

机译：使用海马萎缩率和统计形状模型来预测轻度认知障碍转换为阿尔茨海默氏病的能力不断增强
5. Predicting trajectory of cognitive change in patients with Mild Cognitive Impairment. [D] . Xie, Haiqun. 2011

机译：预测轻度认知障碍患者的认知变化轨迹。
6. A Comprehensive Visual Rating Scale for Predicting Progression from Mild Cognitive Impairment to Dementia in Patients with Alzheimers Pathology or Suspected Non-Alzheimers Pathology [O] . Sang Won Park, Seongheon Kim, Jeonghoon Park, 2020

机译：一种全面的视觉评级规模用于预测对阿尔茨海默病病病理或疑似非阿尔茨海默病理论的轻度认知障碍对痴呆症的进展
7. A Comprehensive Visual Rating Scale for Predicting Progression from Mild Cognitive Impairment to Dementia in Patients with Alzheimer's Pathology or Suspected Non-Alzheimer's Pathology [O] . Sang Won Park, Seongheon Kim, Jeonghoon Park, 2020

机译：一种全面的视觉评级规模，用于预测对阿尔茨海默病病病理或疑似非阿尔茨海默病理论的轻度认知障碍对痴呆症的进展

The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report

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