Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study

Burnham Samantha C.; Bourgeat Pierrick; Dore Vincent; Savage Greg; Brown Belinda; Laws Simon; Maruff Paul; Salvado Olivier; Ames David; Martins Ralph N.; Masters Colin L.; Rowe Christopher C.; Villemagne Victor L.

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Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study

机译：具有可疑的非阿尔茨海默氏病病理生理学（SNAP）或阿尔茨海默氏病病理学的认知健康老年人的临床和认知轨迹：一项纵向研究

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Background Brain amyloid beta (A beta) deposition and neurodegeneration have been documented in about 50-60% of cognitively healthy elderly individuals (aged 60 years or older). The long-term cognitive consequences of the presence of Alzheimer's disease pathology and neurodegeneration, and whether they have an independent or synergistic effect on cognition, are unclear. We aimed to characterise the long-term clinical and cognitive trajectories of healthy elderly individuals using a two-marker (Alzheimer's disease pathology and neurodegeneration) imaging construct.

机译：背景技术在大约50-60％的认知健康的老年人（年龄在60岁以上）中，已有大脑淀粉样蛋白（A beta）沉积和神经变性的文献报道。目前尚不清楚阿尔茨海默氏病病理和神经退行性变的长期认知后果，以及它们是否对认知具有独立或协同作用。我们旨在使用两个标记（阿尔茨海默氏病病理和神经退行性变）成像结构来表征健康老年人的长期临床和认知轨迹。

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《Lancet Neurology》 |2016年第10期|共10页
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Burnham Samantha C.; Bourgeat Pierrick; Dore Vincent; Savage Greg; Brown Belinda; Laws Simon; Maruff Paul; Salvado Olivier; Ames David; Martins Ralph N.; Masters Colin L.; Rowe Christopher C.; Villemagne Victor L.;
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中图分类神经病学与精神病学;
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1. Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study [J] . Burnham Samantha C., Bourgeat Pierrick, Dore Vincent, Lancet Neurology . 2016,第10期

机译：具有可疑的非阿尔茨海默氏病病理生理学（SNAP）或阿尔茨海默氏病病理学的认知健康老年人的临床和认知轨迹：一项纵向研究
2. Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology [J] . Schreiber Stefanie, Schreiber Frank, Lockhart Samuel N., JAMA neurology . 2017,第6期

机译：具有疑似非阿尔茨海默病病理生理学的轻度认知障碍中的阿尔茨海默病签名神经变性和ApoE基因型
3. The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report [J] . Chung Jun Ku, Plitman Eric, Nakajima Shinichiro, Journal of Alzheimer's disease: JAD . 2017,第2期

机译：用疑似非阿尔茨海默病理论对轻度认知障碍临床术后临床轨迹的影响：简要报道
4. Early Detection of Mild Cognitive Impairment and Mild Alzheimer's Disease in Elderly using CBF Activation during Verbally-based Cognitive Tests [C] . Shohei Kato, Hidetoshi Endo, Risako Nagata, International Conference on Health Informatics . 2014

机译：在基于口头的认知测试期间使用CBF激活的老年人患者轻度认知障碍和轻度阿尔茨海默病的早期发现
5. Effects of Apolipoprotein Genotype on the Longitudinal Trajectory of Cognitive Processing Speed Performance in Healthy Elderly Subjects. [D] . Yi, Dahyun. 2012

机译：载脂蛋白基因型对健康老年人认知加工速度表现的纵向轨迹的影响。
6. Alzheimer Disease Pathology in Cognitively Healthy Elderly:A Genome-wide Study [O] . Patricia L Kramer, Haiyan Xu, Randall L Woltjer, -1

机译：阿尔茨海默病病理学在认知健康老年人：全基因组研究
7. 18F-FDG PET Database of Longitudinally Confirmed Healthy Elderly Individuals Improves Detection of Mild Cognitive Impairment and Alzheimer's Disease [O] . L. Mosconi, W. H. Tsui, A. Pupi, 2007

机译：18F-FDG纵向证实健康老年人的宠物数据库改善了对轻度认知障碍和阿尔茨海默病的检测

Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study

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