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首页> 外文期刊>Biotechnology Advances: An International Review Journal >Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for the production of L-threonine
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Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for the production of L-threonine

机译：大肠杆菌和谷氨酸棒杆菌的代谢工程，用于生产L-苏氨酸

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摘要

L-threonine is an essential amino acid for mammals and as such has a wide and expanding application in industry with a fast growing market demand. The major method of production of L-threonine is microbial fermentation. To optimize L-threonine production the fundamental solution is to develop robust microbial strains with high productivity and stability. Metabolic engineering provides an effective alternative to the random mutation for strain development. In this review, the updated information on genetics and molecular mechanisms for regulation of L-threonine pathways in Escherichia coil and Corynbacterium glutamicum are summarized, including L-threonine biosynthesis, intracellular consumption and trans-membrane export. Upon such knowledge, genetically defined L-threonine producing strains have been successfully constructed, some of which have already achieved the productivity of industrial producing strains. Furthermore, strategies for strain construction are proposed and potential problems are identified and discussed. Finally, the outlook for future strategies to construct industrially advantageous strains with respect to recent advances in biology has been considered
机译：L-苏氨酸是哺乳动物必需的氨基酸，因此在市场需求迅速增长的工业中具有广泛且不断扩展的应用。生产L-苏氨酸的主要方法是微生物发酵。要优化L-苏氨酸的生产，根本的解决方案是开发出具有高生产率和稳定性的强大的微生物菌株。代谢工程为随机突变提供了有效的替代方法，用于菌株开发。在这篇综述中，总结了关于大肠杆菌和谷氨酸棒杆菌中L-苏氨酸途径调控的遗传学和分子机制的最新信息，包括L-苏氨酸的生物合成，细胞内消耗和跨膜输出。基于这些知识，已经成功地构建了遗传定义的生产L-苏氨酸的菌株，其中一些已经实现了工业生产菌株的生产率。此外，提出了应变构建策略，并确定和讨论了潜在问题。最后，考虑了关于生物学的最新进展构建工业上有利菌株的未来策略的前景

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