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首页> 外文期刊>Journal of drug delivery science and technology >Formulation of amlodipine nano lipid carrier: Formulation design, physicochemical and transdermal absorption investigation
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Formulation of amlodipine nano lipid carrier: Formulation design, physicochemical and transdermal absorption investigation

机译：制剂氨氯地平纳米脂质载体：配方设计，物理化学和透皮吸收研究

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The present work was designed to formulate and statistically optimize transdermal amlodipine nanostructured lipid carriers (AMNLCs) using lipid blends. The formulation was optimized by using the independent variables Peceol (liquid lipid as X-1), GMS (solid lipid as X-2) and Tween-80 concentration (surfactant as X-3). Their effects were assessed on dependent variables particle size (Y-1), transdermal flux (Y-2), and entrapment efficiency (Y-3). The optimized formulation was further evaluated for in vitro drug release, confocal laser scanning microscopy, physicochemical evaluation, and in-vivo absorption study. The optimized amlodipine nanostructured lipid carriers (AMNLCopt) showed low particle size (123.8 nm), enhanced transdermal flux (58.33 mu g/cm(2)/h), and higher entrapment efficiency (88.11%). Further, it showed prolonged drug release and followed higuchi release kinetics with R-2 closer to unity. The rhodamine red (RR) loaded RR-AMNLCopt revealed an enhanced permeation to the deeper layer of the skin after assessing through confocal laser scanning microscopy (CLSM). The in-vivo absorption study presented enhanced improvement in bioavailability of amlodipine in the wistar rats. From the study, it was concluded that the experimental design based AMNLCs showed the quadratic relationship between independent and dependent variables and also found to be a proficient carrier for transdermal delivery of amlodipine.
机译：设计本工作以使用脂质共混物配制和统计地优化透皮氨咪脂纳米结构脂质载体（AMNLC）。通过使用独立变量磷酸（液体脂质为X-1），GMS（固体脂质为X-2）和吐温-80浓度（表面活性剂为X-3）来优化制剂。它们对依赖变量粒度（Y-1），透皮通量（Y-2）和熵效率（Y-3）进行评估它们的效果。进一步评估优化的制剂，用于体外药物释放，共焦激光扫描显微镜，物理化学评估和体内吸收研究。优化的氨基氨基纳米结构脂质载体（AMNLCOPT）显示出低粒径（123.8nm），增强的透皮通量（58.33μg/ cm（2）/ h），夹杂物效率较高（88.11％）。此外，它显示出延长的药物释放，并随后与R-2更接近统一的HIGUCHI释放动力学。 RRODINE RR-AMNLCOPT的RRODINE红色（RR）揭示了通过共聚焦激光扫描显微镜（CLSM）评估后对皮肤深层的增强渗透。体内吸收研究提高了Wistar大鼠在氨氯堇的生物利用度的提高。从研究来看，得出的结论是，基于实验设计的AMLC在独立和依赖性变量之间表现出二次关系，并且发现是氨氯地平的透皮递送的熟练载体。

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