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首页> 外文期刊>Journal of dermatological science >Dietary glucosylceramide improves skin barrier function in hairless mice.
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Dietary glucosylceramide improves skin barrier function in hairless mice.

机译：膳食葡萄糖基酰胺在无毛老鼠中提高了皮肤屏障功能。

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BACKGROUND: Sphingolipids are known to play an important role in both water retention and epidermal permeability barrier function in mammalian stratum corneum. However, little is known about the effects on epidermal function of orally administered sphingolipids. OBJECTIVE: We examined the effect of dietary glucosylceramide (GluCer) on the maintenance and recovery of epidermal barrier function. METHODS: Hairless mice were fed a particular diet (HR-AD) for 4 weeks to induce chronic skin perturbation. Subsequently, a normal diet supplemented with GluCer (from rice bran and germ) was provided for the next 4 weeks. Transepidermal water loss (TEWL) and stratum corneum flexibility were measured throughout this recovery phase. Additional hairless mice were fed a diet with or without a maize-extracted GluCer supplement for 5 weeks, then their skin was acutely perturbed with repeated tape-stripping, and the TEWL was measured. RESULTS: Although skin functions were generally lower following chronic perturbation, in GluCer-fed mice the TEWL was significantly reduced at 2 weeks and the stratum corneum flexibility was increased at 3 weeks compared to controls. Following acute barrier perturbation by tape-stripping, mice an HR-AD fed a GluCer diet exhibited enhanced recovery compared with the control diet group. CONCLUSION: These results demonstrate that in hairless mice skin barrier functions impaired by chronic or acute perturbations were improved by dietary GluCer. The oral administration of GluCer may be useful for the preservation and recovery of epidermal barrier functions an HR-AD.
机译：背景：已知鞘脂脂在哺乳动物角质层中的水保留和表皮渗透性屏障功能中起重要作用。然而，关于口服给药鞘脂的表皮功能的影响很少。目的：我们研究了膳食葡萄糖胺（Glucer）对表皮屏障功能维持和恢复的影响。方法：无毛小鼠喂食特定的饮食（HR-AD）4周，诱导慢性皮肤扰动。随后，在接下来的4周内提供了补充有凝聚蛋白（来自米糠和胚芽）的正常饮食。在整个恢复阶段测量Transepidermal水分损失（TEWL）和角质层柔韧性。额外的无毛小鼠喂食或没有玉米提取的血糖补充剂的饮食5周，然后它们的皮肤急性扰动，重复的胶带剥离，并测量TEWL。结果：虽然在慢性扰动后，皮肤功能均较低，但在凝血剂喂食小鼠中，TEWL在2周内显着降低，与对照相比，3周内增加了角质层柔韧性。在通过卷尺急性阻隔扰动之后，与对照饮食组相比，小鼠喂食喂养Glucer饮食的HR-Ad表现出增强的恢复。结论：这些结果表明，在无毛的小鼠皮肤屏障功能中，膳食诱导患者通过慢性或急性扰动损害。缩血剂的口服给药可用于保存和恢复表皮阻隔功能的HR-AD。

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