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首页> 外文期刊>Journal of endometriosis. >Adult stem cells in the pathogenesis and treatment of endometriosis
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Adult stem cells in the pathogenesis and treatment of endometriosis

机译：成人干细胞在发病机制和治疗子宫内膜异位症

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摘要

The human endometrium is a dynamic tissue that undergoes approximately 400 cyclical episodes of proliferation, differentiation, shedding, and regeneration in a woman's reproductive lifespan. The regenerative capacity of human endometrium is likely mediated by adult stem cells. At the cellular level, endometrial mesenchymal stem/ stromal cells, located in both the functionalis and basalis layers, support regeneration of the stromal vascular compartment and epithelial progenitor cells, postulated to reside in the basalis epithelium, likely regenerate the glands. Bone marrow adult stem cells, including endothelial progenitor cells, may also participate. Endometriosis can be considered an endometrial proliferative disorder due to dysregulation of the cellular and molecular regenerative processes.Endometriosis is primarily thought to occur via retrograde menstruation of endometrial debris. It is postulated that endometrial stem/progenitor cells, which have been identified in menstrual blood, are shed into the peritoneal cavity where they adhere to pelvic organs and initiate endometriotic lesions. The homing of bone-marrow-derived adult stem cells to endometriotic lesions is thought to drive progression of the disease.New drug therapies are urgently required for the treatment of endometriosis due to frequent disease recurrence with current surgical or medical treatments. Medications directly targeting endometrial stem/progenitor cells during menstruation, or following surgery, or targeting bone marrow cell trafficking, are potential targets for future therapies to manage disease initiation and progression.In this review, we will summarize the current literature on adult stem cell contributions to the development of endometriosis and will then examine the current potential therapies that may target endometrial stem/progenitor cells.
机译：人的子宫内膜是一种动态组织，在女性的生殖寿命中经历大约400个循环发作，分化，脱落和再生。人体子宫内膜的再生能力可能由成体干细胞介导。在细胞水平，子宫内膜间充质茎/基质细胞中，位于功能性和基础层中，基质血管室和上皮祖细胞的支撑再生，假设在基底上皮，可能会再生腺体。骨髓成年干细胞（包括内皮祖细胞）也可能参与。子宫内膜异位症可以被认为是由于细胞和分子再生过程的失调引起的子宫内膜增殖性疾病。主要是通过逆行月经的子宫内膜碎片来进行术语去除症。假设已在经期血液中鉴定的子宫内膜茎/祖细胞脱落到腹膜腔中，它们粘附在盆腔器官中并引发内膜静脉病变。骨髓衍生的成年干细胞归巢至内膜静脉病变，以驱动疾病的进展。迫切需要药物治疗子宫内膜异位症，由于频繁的疾病复发，目前的外科手术或医学治疗。直接靶向月经期间的子宫内膜茎/祖细胞，或在手术后或靶向骨髓细胞贩运期间的药物是未来治疗疾病启动和进展的潜在目标。在本综述中，我们将总结当前的成人干细胞贡献文献为了产生子宫内膜异位症，然后检查可能靶向子宫内膜茎/祖细胞的电流潜在疗法。

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