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首页> 外文期刊>Biotechnology Advances: An International Review Journal >Nanoencapsulation of polyphenols for protective effect against colon-rectal cancer. (Special Issue: Pearl (30th) Anniversary Edition: Nanotechnology and regenerative medicine.)
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Nanoencapsulation of polyphenols for protective effect against colon-rectal cancer. (Special Issue: Pearl (30th) Anniversary Edition: Nanotechnology and regenerative medicine.)

机译：纳米囊化多酚对结肠直肠癌的保护作用。 （特刊：珍珠（第30周年）版：纳米技术和再生医学。）

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摘要

The human population at large is exposed to many critical factors (e.g. bad food habits, chemical substances, and stress) leading to the development of serious diseases. Colon or colorectal cancer is one of the most prevalent types of cancer in many countries. Despite being a multi-factorial chronic disease, resulting from the interaction of multiple genetic and environmental factors, the critical factor is mostly a poor diet regimen. Therefore, an accumulation of constant mutations leads to a complex arrangement of events during tumor initiation, development and propagation. It is well known that many plants are rich in polyphenols with anti-oxidant, anti-atherogenic, anti-diabetic, anti-cancer, anti-viral, and anti-inflammatory properties. These compounds are secondary metabolites with the ability to donate electrons to free radicals through different mechanisms. In recent years, a large number of studies have attributed a protective effect to polyphenols and foods containing these compounds (e.g. plants, vegetables, cereals, tea, coffee or chocolate). Polyphenolic compounds have been described to inhibit cancer development and propagation, being used as chemopreventive agents. Some polyphenols reported a preventive action against colon cancer, e.g. curcumin, gallic acid, ellagic acid, and epigallocatechin-3-gallate. The present article focuses on the properties of these molecules as chemopreventive agents and the recent advances on their formulation in nanoparticulate systems for targeted therapy and increased bioavailability.
机译：整个人口面临许多导致严重疾病发展的关键因素（例如不良的饮食习惯，化学物质和压力）。结肠癌或结直肠癌是许多国家中最普遍的癌症类型之一。尽管是由多种遗传和环境因素共同作用导致的多因素慢性疾病，但关键因素主要是不良的饮食习惯。因此，恒定突变的积累导致肿瘤发生，发展和扩散期间事件的复杂排列。众所周知，许多植物富含具有抗氧化，抗动脉粥样硬化，抗糖尿病，抗癌，抗病毒和抗炎特性的多酚。这些化合物是次级代谢产物，具有通过不同机制将电子捐赠给自由基的能力。近年来，大量研究归因于多酚和含有这些化合物的食物（例如植物，蔬菜，谷物，茶，咖啡或巧克力）的保护作用。已经描述了多酚化合物用作化学预防剂可抑制癌症的发展和扩散。一些多酚类药物据报道对结肠癌有预防作用。姜黄素，没食子酸，鞣花酸和表没食子儿茶素-3-没食子酸酯。本文重点介绍这些分子作为化学预防剂的特性，以及它们在纳米颗粒系统中的靶向治疗和提高的生物利用度方面的最新进展。

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