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首页> 外文期刊>Biotechnology Advances: An International Review Journal >ORC-associated replication factors as biomarkers for cancer.
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ORC-associated replication factors as biomarkers for cancer.

机译：ORC相关的复制因子作为癌症的生物标记。

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Early detection and treatment of cancer are of central importance to improving patient prognoses. Traditional biomarkers of cell proliferation, such as Ki-67 and PCNA, have had a mixed clinical track record, proving to be good indicators of certain types of cancers but of limited use for many others. Recently, human counterparts of replication factors originally identified in budding yeast have shown great promise as new cancer biomarkers. Each of these factors has been shown to interact with the origin recognition complex (ORC) in yeast, and each has an essential role in the initiation of DNA replication. Studies with minichromosome maintenance (MCM) family proteins show that their levels are upregulated in tumor cells and are much better indicators of a wide variety of cancers than traditional biomarkers. Similarly encouraging results have been obtained in preliminary studies examining Cdc6 protein and Cdc7 kinase transcript levels in normal and cancerous cells.
机译：癌症的早期发现和治疗对于改善患者的预后至关重要。传统的细胞增殖生物标志物，例如Ki-67和PC​​NA，在临床上有混杂的记录，被证明是某些类型癌症的良好指标，但在许多其他类型癌症中的用途有限。最近，最初在发芽酵母中鉴定的人类复制因子对应物已显示出作为新的癌症生物标记物的巨大希望。这些因素中的每一个都已显示出与酵母中的起源识别复合物（ORC）相互作用，并且在DNA复制的起始过程中都起着至关重要的作用。微型染色体维持（MCM）家族蛋白的研究表明，其水平在肿瘤细胞中上调，并且比传统生物标记物更好地指示了多种癌症。在检查正常细胞和癌细胞中Cdc6蛋白和Cdc7激酶转录水平的初步研究中，也获得了类似的令人鼓舞的结果。

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