Synthesis and Anti-proliferative Activity of N,N '-bis-substituted 1,2,4-Triazolium Salts against Breast Cancer and Prostate Cancer Cell Lines

Lin Zi Jie; Bies Jared; Johnson Shanina S.; Gorden John D.; Strickland Jacqueline F.; Frazier Monica; Meyers Jonathan M.; Shelton Kerri L.

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Synthesis and Anti-proliferative Activity of N,N '-bis-substituted 1,2,4-Triazolium Salts against Breast Cancer and Prostate Cancer Cell Lines

机译：N，N'-BIS取代的1,2,4-三唑盐对乳腺癌和前列腺癌细胞系的合成和抗增殖活性

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摘要

A series of 1,4-N,N '-bis-substituted 1,2,4-triazolium bromide salts were synthesized and tested for anti-proliferative activity. 1,4-Bis(naphthalen-2-ylmethyl)-1,2,4-triazolium bromide (2) showed activity against MDA-MB-468 breast cancer and PC-3 prostate cancer cell lines.

机译：合成并测试了一系列1,4-N，N'-BIS取代的1,2,4-三唑溴盐以进行抗增殖活性。 1,4-BIS（萘-2-基甲基）-1,2,4-三唑溴（2）显示对MDA-MB-468乳腺癌和PC-3前列腺癌细胞系的活性。

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《Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry》 |2019年第2期|共6页
作者
Lin Zi Jie; Bies Jared; Johnson Shanina S.; Gorden John D.; Strickland Jacqueline F.; Frazier Monica; Meyers Jonathan M.; Shelton Kerri L.;
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Columbus State Univ Dept Chem Columbus GA 31907 USA;

Columbus State Univ Dept Chem Columbus GA 31907 USA;

Spelman Coll Dept Chem Atlanta GA 30314 USA;

Auburn Univ Dept Chem Auburn AL 36849 USA;

Columbus State Univ Dept Chem Columbus GA 31907 USA;

Columbus State Univ Dept Biol Columbus GA 31907 USA;

Columbus State Univ Dept Chem Columbus GA 31907 USA;

Columbus State Univ Dept Chem Columbus GA 31907 USA;

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正文语种 eng
中图分类有机化学;
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1. Synthesis and Anti-proliferative Activity of N,N '-bis-substituted 1,2,4-Triazolium Salts against Breast Cancer and Prostate Cancer Cell Lines [J] . Lin Zi Jie, Bies Jared, Johnson Shanina S., Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 2019,第2期

机译：N，N'-BIS取代的1,2,4-三唑盐对乳腺癌和前列腺癌细胞系的合成和抗增殖活性
2. Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines [J] . Mandalapu Dhanaraju, Saini Karan S., Gupta Sonal, Bioorganic and Medicinal Chemistry Letters . 2016,第17期

机译：姜黄素模拟物的一些新型三唑杂化物的合成，生物学评估及其对乳腺癌和前列腺癌细胞系的选择性抗癌活性
3. Enantiomerically pure (1, 2-diamino-1-(4-fluorophenyl)butane)platinum(II) complexes: synthesis and antitumor activity against MCF-7 and MDA-MB 231 breast cancer and LnCaP/FGC prostate cancer cell lines. [J] . Dullin A, Dufrasne F, Gelbcke M, Archiv der Pharmazie . 2004,第12期

机译：对映体纯的（1，2-二氨基-1-（4-氟苯基）丁烷）铂（II）配合物：对MCF-7和MDA-MB 231乳腺癌和LnCaP / FGC前列腺癌细胞系的合成和抗肿瘤活性。
4. The anti-proliferative activity of D-mannoheptulose against breast cancer cell line through glycolysis inhibition [C] . Ahmed Ghdhban Al-Ziaydi, Mohammed I. Hamzah, Ahmed Majeed Al-Shammari, Technologies and Materials for Renewable Energy, Environment and Sustainability (conference) . 2020

机译：乙醇分析抑制抑制乳腺癌细胞D-甘露出的抗增殖活性
5. Cytotoxic Activity of Verbenaceae (Daniellia oliveri) & Solanaceae (Capsicum frutescens) on Breast Cancer, Prostate Cancer, and Colon Cancer cells. [D] . Howard, Kareem Sharif. 2011

机译：马鞭草科（Daniellia oliveri）和茄科（Capsicum frutescens）对乳腺癌，前列腺癌和结肠癌细胞的细胞毒活性。
6. Synthesis anti-proliferative activity SAR study and preliminary in vivo toxicity study of substituted NN′-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines [O] . Kerri L. Shelton, Michael A. DeBord, Patrick O. Wagers, -1

机译：取代的NN-双（芳基甲基）苯并咪唑鎓盐对一组非小细胞肺癌细胞系的合成抗增殖活性SAR研究和体内初步毒性研究
7. Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,N′-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines [O] . Kerri L. Shelton, Michael A. DeBord, Patrick O. Wagers, 2017

机译：对非小细胞肺癌细胞面板的已取代的N，N'-BIS（芳基甲基）苯并咪唑鎓盐的合成，抗增殖活性，SAR研究和初步研究

Synthesis and Anti-proliferative Activity of N,N '-bis-substituted 1,2,4-Triazolium Salts against Breast Cancer and Prostate Cancer Cell Lines

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