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首页> 外文期刊>Journal of industrial and engineering chemistry >NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy
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NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy

机译:NIR染料装载的介孔二氧化硅纳米粒子用于多功能治疗平台:肿瘤和缺血性病变的可视化,以及光热疗法的性能

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摘要

We report the fabrication of multifunctional theranositic biomaterials via non-covalent, rapid, and effective encapsulation of 1,1'dioctadecyl-3,3,3',3'-tetrametylindotrucarbocyanine iodide (DIR) onto mesoporous silica nanoparticles by coating the surface of polyethylene glycol (PEG-DIR@MSN). PEG-DIR@MSNs exhibited great stability with excellent biocompatibility and photothermal conversion properties. PEG-DIR@MSN allowed for not only the detection of various types of tumor and ischemic lesions but also photothermal therapy against breast cancer in living mice, suggesting that PEGDIR@MSN is a valuable multifunctional theranostic platform. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
机译:通过涂覆聚乙烯表面,通过非共价,快速和有效包封的1,1'二℃-3,3,3',3'-四乙烯基茚满索碳酰胺碘化物(DIR)通过非共价,快速和有效的包封制备多功能治疗生物材料的制备,通过涂覆聚乙烯表面 乙二醇(PEG-DIR @ MSN)。 PEG-DIR @ MSNS表现出具有优异的生物相容性和光热转化性能的稳定性。 PEG-DIR @ MSN不仅可以检测各种类型的肿瘤和缺血性病变,而且还允许在生物小鼠中对乳腺癌进行光热疗法,表明PEGDIR @ MSN是一个有价值的多功能治疗平台。 (c)2020朝鲜工业与工程化学学会。 elsevier b.v出版。保留所有权利。

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