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首页> 外文期刊>Journal of investigative medicine >Efficacy of interventions for adherence to the immunosuppressive therapy in kidney transplant recipients: a meta-analysis and systematic review
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Efficacy of interventions for adherence to the immunosuppressive therapy in kidney transplant recipients: a meta-analysis and systematic review

机译：干预措施依赖于肾移植受者的免疫抑制治疗的疗效：Meta分析和系统审查

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摘要

Immunosuppressive treatment regimens are complex and require ongoing self-management. Medication adherence can be difficult to achieve for several reasons. The current meta-analysis and systematic review investigated whether adherence interventions improved immunosuppressive treatment adherence in kidney transplant recipients. Medline, Cochrane, EMBASE, and Google Scholar were searched until October 17, 2016 using the following search terms: kidney transplantation, compliance, adherence, and immunosuppressive therapy. Randomized controlled trials and two-arm prospective, retrospective, and cohort studies were included. The primary outcomes were adherence rate and adherence score. Eight studies were included with a total for 546 patients. Among participants receiving intervention, the adherence rate was significantly higher than the control group (pooled OR=2.366, 95% CI 1.222 to 4.578, p=0.011). Participants in the intervention group had greater adherence scores than those in the control group (pooled standardized difference in means =1.706, 95% CI 0.346 to 3.065, p=0.014). Sensitivity analysis indicated that findings for adherence rate were robust. However, for adherence score, the significance of the association disappeared after removing one of the studies indicating the findings may have been overly influenced by this one study. Intervention programs designed to increase immunosuppressive adherence in patients with kidney transplant improve treatment adherence.
机译：免疫抑制治疗方案很复杂，需要持续的自我管理。由于几种原因，难以实现的药物粘附。目前的荟萃分析和系统评论研究了依从性干预是否改善了肾移植受者的免疫抑制治疗依从性。在2016年10月17日之前搜索了Medline，Cochrane，Embase和Google学者：肾移植，遵守，依从性和免疫抑制治疗。包括随机对照试验和双臂前瞻性，回顾性和队列研究。主要结果是依从性率和依从性得分。 546名患者共用八项研究。在接受干预的参与者中，依从性率明显高于对照组（汇集或= 2.366,95％CI 1.222至4.578，P = 0.011）。干预组的参与者具有比对照组的依赖性得分更大（汇集标准化差异= 1.706,95％CI 0.346至3.065，P = 0.014）。敏感性分析表明，遵守率的结果是强大的。然而，对于依从性得分，在去除其中一个研究后，关联的重要性消失了，该研究表明该研究结果可能受到这项研究的过度影响。旨在提高肾移植患者免疫抑制性的干预计划改善治疗依从性。

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  • 来源
    《Journal of investigative medicine》 |2017年第7期|共8页
  • 作者

    Zhu Yichen; Zhou Yifan; Zhang Lei; Zhang Jian; Lin Jun;

  • 作者单位

    Capital Med Univ Beijing Friendship Hosp Dept Urol 95 Yongan Rd Beijing 100050 Peoples R China;

    NIDDK Bethesda MD 20892 USA;

    Capital Med Univ Beijing Friendship Hosp Dept Urol 95 Yongan Rd Beijing 100050 Peoples R China;

    Capital Med Univ Beijing Friendship Hosp Dept Urol 95 Yongan Rd Beijing 100050 Peoples R China;

    Capital Med Univ Beijing Friendship Hosp Dept Urol 95 Yongan Rd Beijing 100050 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 诊断学;
  • 关键词

    Immunosuppression; Kidney Transplantation;

    机译：免疫抑制;肾移植;

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