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首页> 外文期刊>Journal of mass spectrometry: JMS >Characterization of complex, heterogeneous lipid A samples using HPLC‐MS/MS technique III. Positive‐ion mode tandem mass spectrometry to reveal phosphorylation and acylation patterns of lipid A
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Characterization of complex, heterogeneous lipid A samples using HPLC‐MS/MS technique III. Positive‐ion mode tandem mass spectrometry to reveal phosphorylation and acylation patterns of lipid A

机译：使用HPLC-MS / MS技术III的复合物，非均相脂质的特征。 正离子模式串联质谱，显示脂质A的磷酸化和酰化图案

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Abstract > In this study, we report the detailed analysis of the fragmentation patterns of positively charged lipid A species based on their tandem mass spectra obtained under low‐energy collision‐induced dissociation conditions of an electrospray quadrupole time‐of‐flight mass spectrometer. The tandem mass spectrometry experiments were performed after the separation of the compounds with a reversed‐phase high performance liquid chromatography method. We found that both, phosphorylated and nonphosphorylated lipid A molecules can be readily ionized in the positive‐ion mode by adduct formation with triethylamine added to the eluent. The tandem mass spectra of the lipid A triethylammonium adduct ions showed several product ions corresponding to inter‐ring glycosidic cleavages of the sugar residues, as well as consecutive and competitive eliminations of fatty acids, phosphoric acid, and water following the neutral loss of triethylamine. Characteristic product ions provided direct information on the phosphorylation site(s), also when phosphorylation isomers (ie, containing either a C1 or a C4′ phosphate group) were simultaneously present in the sample. Continuous series of high‐abundance B‐type and low‐abundance Y‐type inter‐ring fragment ions were indicative of the fatty acyl distribution between the nonreducing and reducing ends of the lipid A backbone. The previously reported lipid A structures of <fi>Proteus morganii</fi> O34 and <fc> <fi>Escherichia coli</fi> </fc> O111 bacteria were used as standards. Although, the fragmentation pathways of the differently phosphorylated lipid A species significantly differed in the negative‐ion mode, they were very similar in the positive‐ion mode. The complementary use of positive‐ion and negative‐ion mode tandem mass spectro </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> >研究，我们报告了基于在电喷雾四极其飞行时间谱仪的低能量碰撞诱导的解离条件下获得的串联质谱对正电荷脂质的碎片模式的详细分析。用反相高效液相色谱法分离化合物后进行串联质谱实验。我们发现，通过加入三乙胺加入洗脱液，可以在正离子模式下易于离子，磷酸化和非磷酸化脂质分子。脂质的串联质谱分三乙基铵加合离子显示出几种对应于糖残基的环形糖糖分裂的产物离子，以及在三乙胺的中性丧失之后脂肪酸，磷酸和水的连续和竞争消除。特征产物离子在样品中同时存在磷酸化异构体（即，含有C1或C 4'磷酸基团）时，还提供了关于磷酸化位点的直接信息。连续系列高丰度B型和低丰度Y型环形片段离子指示脂质的脂质末端之间的脂肪酰基分布。先前报道的脂质是<fi>蛋白质morganii </ fi> o34和<fc> <fi>大肠杆菌</ fi> </ fc> o111细菌的结构用作标准。虽然，不同磷酸化脂质的碎裂途径在负离子模式中显着不同，它们在正离子模式中非常相似。正离子和负离子模式串联质谱的互补使用 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2018年第2期</span><b style="margin: 0 2px;">|</b><span>共16页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sándor Viktor&option=202" target="_blank" rel="nofollow">Sándor Viktor;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kilár Anikó&option=202" target="_blank" rel="nofollow">Kilár Anikó;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kilár Ferenc&option=202" target="_blank" rel="nofollow">Kilár Ferenc;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kocsis Béla&option=202" target="_blank" rel="nofollow">Kocsis Béla;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=D?rnyei ágnes&option=202" target="_blank" rel="nofollow">D?rnyei ágnes;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Institute of Bioanalysis Medical School and Szentágothai Research CentreUniversity of PécsSzigeti út 12 7624 Pécs Hungary;</p> <p>Institute of Bioanalysis Medical School and Szentágothai Research CentreUniversity of PécsSzigeti út 12 7624 Pécs Hungary;</p> <p>Institute of Bioanalysis Medical School and Szentágothai Research CentreUniversity of PécsSzigeti út 12 7624 Pécs Hungary;</p> <p>Department of Medical Microbiology and Immunology Medical SchoolUniversity of PécsSzigeti út 12 7624 Pécs Hungary;</p> <p>Department of Analytical and Environmental Chemistry Faculty of SciencesUniversity of PécsIfjúság útja 6 7624 Pécs Hungary;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=fragmentation pathway&option=203" rel="nofollow">fragmentation pathway;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=lipid A structure&option=203" rel="nofollow">lipid A structure;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=phosphorylation site&option=203" rel="nofollow">phosphorylation site;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=positive‐ion mode&option=203" rel="nofollow">positive‐ion mode;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=tandem mass spectrometry&option=203" rel="nofollow">tandem mass spectrometry;</a> </p> <div class="translation"> 机译：碎片途径;脂质的结构;磷酸化位点;正离子模式;串联质谱; 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