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Investigation of sarin(Se) reactivity against human plasma proteins using liquid chromatography–tandem mass spectrometry

机译：使用液相色谱 - 串联质谱法对人血浆蛋白的Sarin（SE）反应性研究

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Abstract > Electron ionization mass spectrum of sarin(Se) was interpreted in compare of sarin MS spectrum. Inhibition of butyrylcholinesterase of human plasma by sarin and sarin(Se) was determined spectrophotometrically using modified Ellman method. It appeared that after incubation with sarin and sarin(Se), cholinesterase inhibition were 93% and 83%, respectively. Sarin, sarin(Se), and sarin(Se)‐d <sub>7</sub> were spiked into a vial containing human plasma, and albumin adduct metabolites were identified using liquid chromatography–tandem mass spectrometry. The experiments show that these agents are attached to tyrosine on albumin in human blood. Corresponding deuterated adducts were used to confirm the proposed mechanisms for the formation of the fragments in mass spectrometry experiments. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <标题类型=“main”>抽象</ title> >电子电离在比较Sarin MS谱的比较中解释了Sarin（Se）的质谱。使用修饰的Ellman方法测定Sarin和Sarin（SE）通过修饰的Ellman方法测定抑制人血浆的丁酰胆碱酯酶。它似乎与Sarin和Sarin（Se）孵育后，胆碱酯酶抑制分别为93％和83％。 SARIN，SARIN（SE）和SARIN（SE）-D <亚> 7 </ sup>掺入含有人血浆的小瓶中，使用液相色谱 - 串联质谱法鉴定白蛋白加合物代谢物。实验表明，这些试剂在人血液中的白蛋白上附着在酪氨酸上。相应的氘代加合物用于确认所提出的机制，用于形成质谱中的碎片。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2018年第2期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Saeidian Hamid&option=202" target="_blank" rel="nofollow">Saeidian Hamid;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hosseini Seyed Esmaeil&option=202" target="_blank" rel="nofollow">Hosseini Seyed Esmaeil;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Amoozadeh Ali&option=202" target="_blank" rel="nofollow">Amoozadeh Ali;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Naseri Mohammad Taghi&option=202" target="_blank" rel="nofollow">Naseri Mohammad Taghi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Babri Mehran&option=202" target="_blank" rel="nofollow">Babri Mehran;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of SciencePayame Noor University (PNU)PO Box 19395‐4697 Tehran Iran;</p> <p>Department of ChemistrySemnan UniversityPO Box 35131‐19111 Semnan Iran;</p> <p>Department of ChemistrySemnan UniversityPO Box 35131‐19111 Semnan Iran;</p> <p>Defense Chemical Research Lab (DCRL)PO Box 31585‐1461 Karaj Iran;</p> <p>Defense Chemical Research Lab (DCRL)PO Box 31585‐1461 Karaj Iran;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=acetylcholinesterase&option=203" rel="nofollow">acetylcholinesterase;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=adduct metabolites&option=203" rel="nofollow">adduct metabolites;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=liquid chromatography–tandem mass spectrometry&option=203" rel="nofollow">liquid chromatography–tandem mass spectrometry;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=sarin&option=203" rel="nofollow">sarin;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=sarin(Se)&option=203" rel="nofollow">sarin(Se);</a> </p> <div class="translation"> 机译：乙酰胆碱酯酶;加合代谢物;液相色谱 - 串联质谱;Sarin;Sarin（SE）; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025633303.html">Investigation of sarin(Se) reactivity against human plasma proteins using liquid chromatography–tandem mass spectrometry</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Saeidian Hamid&option=202" target="_blank" rel="nofollow" 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