...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Medical Virology >Early human enterovirus infections in healthy Swedish children participating in the PRODIA pilot study
【24h】

Early human enterovirus infections in healthy Swedish children participating in the PRODIA pilot study

机译：早期的人类肠道病毒感染健康的瑞典儿童参与Prodia试点研究

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human enteroviruses (HEV) are common, especially in childhood and during the enterovirus season, causing mainly asymptomatic infections but also mild and severe illnesses. Numerous studies have shown the association between HEV infections and type 1 diabetes. Here, the prevalence of HEV infections was studied in healthy Swedish children with increased HLA-associated risk for type 1 diabetes participating in the PRODIA pilot study in which children were randomized to receive probiotics or placebo during the first 6 months of life. Stool specimens collected from 197 children in every 3 months from the age of 3 to 24 months were screened for HEV using traditional viral culturing method and identified with reverse transcriptase polymerase chain reaction (RT-PCR) and sequencing of the partial VP1 coding part of the viral genome. Altogether 4.8% (52/1,094) of the specimens were HEV-positive and 22.3% (44/197) of the children excreted HEV during the follow-up. HEV-A and HEV-B were present in 2.1 and 2.7% of the specimens, respectively. HEV-C and HEV-D viruses were not detected. In total, 17 different HEV serotypes were detected and the most common findings were CV-A9 (13.5%), CV-A16 (11.5%), and CV-A2 (9.6%). The majority of the infections (92.3%) were during the enterovirus season extending from July to December. Probiotic treatment did not affect significantly the risk of HEV infections during the 2-year follow-up although a trend for transient decrease for HEV positivity (HEV-A and/or HEV-B) by the age of 12 months was observed in children who received probiotics [OR 0.40; 95% confidence interval 0.15 to 1.08; P-value 0.071, generalized estimating (GEE) analysis]. According to the results, HEV-A findings were nearly as common as HEV-B findings among the healthy children participating in this study. Also it was shown that serotypes belonging to HEV-A species can be detected by means of viral culturing.
机译：人类肠病毒（HEV）是常见的，特别是在儿童期和肠病病毒季节，导致主要是无症状的感染，但也具有轻度和严重的疾病。许多研究表明HEV感染与1型糖尿病之间的关联。在这里，HEV感染的患病率在健康的瑞典儿童中研究了HLA相关的患有1型糖尿病的风险，参与Prodia试点研究，其中儿童在生命的前6个月内随机接受益生菌或安慰剂。从197名儿童收集的粪便标本每3个月，使用传统的病毒培养方法筛选HEV，并用逆转录酶聚合酶链反应（RT-PCR）鉴定，部分VP1编码部分鉴定病毒基因组。共有4.8％（52/1,094）的标本是HEV阳性和22.3％（44/197）的儿童在随访期间排泄HEV。 HEV-A和HEV-B分别存在于2.1和2.7％的标本中。 HEV-C和HEV-D病毒未被检测到。总共检测到17种不同的HEV血清型，最常见的发现是CV-A9（13.5％），CV-A16（11.5％）和CV-A2（9.6％）。大多数感染（92.3％）是从7月到12月延伸的肠病病毒赛季。益生菌治疗在为期两年的后续行动中，缺乏影响的风险不会影响，尽管在儿童中观察到12个月的阳性阳性（HEV-A和/或HEV-B）的瞬态减少趋势收到益生菌[或0.40; 95％置信区间0.15至1.08; P值0.071，广义估计（GEE）分析。根据结果​​，HEV-A发现几乎与参与本研究的健康儿童中的HEV-B调查结果一样常见。结果表明，可以通过病毒培养检测属于HEV-A物种的血清型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号