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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Construction of nanoscale liposomes loaded with melatonin via supercritical fluid technology
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Construction of nanoscale liposomes loaded with melatonin via supercritical fluid technology

机译：通过超临界流体技术施工含有褪黑激素的纳米镜片脂质体

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摘要

Melatonin-loaded liposomes (MLL) were successfully prepared using rapid expansion of supercritical solution technology. The effects of supercritical pressure on encapsulation efficiency (EE) and average particle size were then analysed. Meanwhile, temperature, formation time and ethanol concentration in the products were studied and optimised based on the response surface methodology (RSM). An in vitro simulated digestion model was also established to evaluate the release performance of MLL. The results showed that 140 bar was the best pressure for maximising the EE value using RSM optimisation, reaching up to 82.2%. MLL characterisations were performed using analytic techniques including infrared spectroscopy, transmission electron microscopy, a laser scattering particle size analyser and gas chromatograph-mass spectrometer. The size distribution was uniform, with an average diameter of 66 nm. Stability tests proved that MLL maintained good preservation duration, and residual solvent experiments indicated that only 1.03% (mass ratio) of ethanol remained in the products. Simulated release experiments indicated the slow release feature in early digestive stages and more thorough characteristics in later stages of simulated digestion.
机译：使用超临界解决方案技术的快速扩展成功制备了褪黑激素脂质体（MLL）。然后分析了超临界压力对封装效率（EE）和平均粒度的影响。同时，基于响应面法（RSM）研究和优化产品中的温度，形成时间和乙醇浓度。还建立了体外模拟消化模型，以评估MLL的释放性能。结果表明，140巴是使用RSM优化最大化EE值的最佳压力，达到高达82.2％。使用包括红外光谱，透射电子显微镜，激光散射粒度分析仪和气相色谱谱仪的分析技术进行MLL特征。尺寸分布均匀，平均直径为66nm。稳定性试验证明，MLL保持了良好的保存持续时间，并且残留的溶剂实验表明，产物中仅为1.03％（质量比）乙醇。模拟释放实验表明早期消化阶段的缓慢释放特征以及在模拟消化的后期阶段的更彻底的特征。

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