Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions

Volgin Andrey D.; Yakovlev Oleg A.; Demin Konstantin A.; de Abreu Murilo S.; Alekseeva Polina A.; Friend Ashton J.; Lakstygal Anton M.; Amstislavskaya Tamara G.; Bao Wandong; Song Cai; Kalueff Allan V.

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Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions

机译：个性化精神病症的斑马鱼模型：来自个体，应变和性别差异的见解，以及基因X环境相互作用

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Currently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing, and high genetic and physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine. Mounting evidence supports zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain, and sex differences shape their CNS responses to genetic, environmental, and pharmacological manipulations. Here, we discuss zebrafish as a promising complementary translational tool to further advance patient-centered personalized psychiatry.

机译：目前被广泛认可，个性化精神病学侧重于患者的独特生理和遗传型材，以最佳量身定制的治疗。然而，人类精神病患者中个人差异以及遗传和环境因素的作用仍然明显。动物实验模型是一种有价值的工具，可以改善我们对疾病病理生理学的理解及其分子机制的理解。由于高再现能力，完全测序的基因组，易基因编辑和与人类的高遗传和生理同源性，斑马鱼（Danio Rerio）正在成为生物医学的新颖强大模型。安装证据支持斑马鱼作为CNS研究中有用的模型生物体。在这些鱼，个体，菌株和性差异中强大地表达了对遗传，环境和药理操纵的CNS反应。在这里，我们将Zebrafish讨论为有前途的互补翻译工具，以进一步推进以患者为中心的个性化精神病学。

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来源
《Journal of Neuroscience Research》 |2019年第4期|共12页
作者
Volgin Andrey D.; Yakovlev Oleg A.; Demin Konstantin A.; de Abreu Murilo S.; Alekseeva Polina A.; Friend Ashton J.; Lakstygal Anton M.; Amstislavskaya Tamara G.; Bao Wandong; Song Cai; Kalueff Allan V.;
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作者单位

Minist Healthcare Russian Federat Almazov Natl Med Res Ctr St Petersburg Russia;

Minist Healthcare Russian Federat Almazov Natl Med Res Ctr St Petersburg Russia;

Minist Healthcare Russian Federat Almazov Natl Med Res Ctr St Petersburg Russia;

Univ Passo Fundo Biosci Inst Passo Fundo Brazil;

Minist Healthcare Russian Federat Almazov Natl Med Res Ctr St Petersburg Russia;

Tulane Univ Sch Sci &

Engn New Orleans LA 70118 USA;

Minist Healthcare Russian Federat Almazov Natl Med Res Ctr St Petersburg Russia;

Sci Res Inst Physiol &

Basic Med Lab Translat Biopsychiat Novosibirsk Russia;

Southwest Univ Sch Pharm Chongqing 400715 Peoples R China;

Guangdong Ocean Univ Res Inst Marine Drugs &

Nutr Zhanjiang Peoples R China;

Southwest Univ Sch Pharm Chongqing 400715 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
gene-environment interactions; individual differences; personalized psychiatry; zebrafish;

机译：基因环境相互作用;个体差异;个性化精神病学;斑马鱼;

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1. Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions [J] . Volgin Andrey D., Yakovlev Oleg A., Demin Konstantin A., Journal of Neuroscience Research . 2019,第4期

机译：个性化精神病症的斑马鱼模型：来自个体，应变和性别差异的见解，以及基因X环境相互作用
2. Preoperative ultraviolet B inflammation in skin: Modelling individual differences in acute postoperative pain and neuro‐immune interactions [J] . Lunn T.H., Dawes J.M., Denk F., European journal of pain : . 2018,第1期

机译：皮肤术前紫外线B炎症：造型急性术后疼痛和神经免疫相互作用的个体差异
3. Genetic Strain and Sex Differences in a Hyperoxia-Induced Mouse Model of Varying Severity of Bronchopulmonary Dysplasia [J] . Leary Sean, Das Pragnya, Ponnalagu Devasena, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2019,第5期

机译：高氧诱导的支气管扩张性异常平移的高氧诱导的小鼠模型中的遗传菌株和性差异
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5. Sex Differences and ApoE4-Estrogen Interaction in Animal Models of Alzheimer's Disease. [D] . Hou, Xu. 2015

机译：阿尔茨海默氏病动物模型中的性别差异和ApoE4-雌激素相互作用。
6. Importance of genetic differences in developmental programming: gene by environment interactions in models of maternal dietary restriction [O] . Laura A Cox, Peter W Nathanielsz 2007

机译：遗传差异在发育计划中的重要性：母体饮食限制模型中环境相互作用下的基因
7. Importance of genetic differences in developmental programming: gene by environment interactions in models of maternal dietary restriction [O] . Cox, Laura A, Nathanielsz, Peter W 2007

机译：遗传差异在发育计划中的重要性：母体饮食限制模型中环境相互作用下的基因

Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions

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