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首页> 外文期刊>American journal of clinical dermatology >Ceftriaxone-induced fixed drug eruption: first report.
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Ceftriaxone-induced fixed drug eruption: first report.

机译：头孢曲松钠引起的固定药疹：首次报告。

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Fixed drug eruption (FDE) is an unusual type of cutaneous adverse drug reaction that is characterized by recurrent site-specific lesions each time the drug responsible is taken. FDE from cephalosporins has been rarely reported, and to the best of our knowledge there is no published report of ceftriaxone-induced FDE in the literature. We report the first case of a 54-year-old Turkish woman who presented with ceftriaxone-induced FDE. Topical provocation with ceftriaxone sodium salt (1% in water [aq.], 5% aq., 10% in petrolatum [pet.], 20% pet.) remained negative both at previously affected sites and in the unaffected skin of the back. Therapeutic re-exposure with intravenous ceftriaxone 1 g confirmed the diagnosis. The patient tolerated amoxicillin and cefazolin, suggesting that the sensitizing portion was not the beta-lactam ring. Identification of the antigenic determinants of FDE-inducing drugs will make predicting safe alternatives in patients with FDE an easier task.
机译：固定药疹（FDE）是一种罕见的皮肤不良药物反应类型，其特征是每次服用负责药物时都会复发特定部位的病变。头孢菌素的FDE鲜有报道，据我们所知，文献中没有头孢曲松诱导的FDE的公开报道。我们报道了头孢曲松诱导的FDE的54岁土耳其妇女的第一例。头孢曲松钠盐的局部刺激（在水中1％，水溶液5％，凡士林[pet。] 10％，宠物20％）在先前受影响的部位和背部未受影响的皮肤中均呈阴性。 。静脉注射头孢曲松1 g进行治疗性再次暴露证实了诊断。该患者耐受阿莫西林和头孢唑林，表明致敏部分不是β-内酰胺环。鉴定FDE诱导药物的抗原决定簇将使预测FDE患者的安全替代方案变得更加容易。

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