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首页> 外文期刊>Journal of Reproductive Immunology >Antiphospholipid syndrome and recurrent miscarriage: A systematic review and meta-analysis
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Antiphospholipid syndrome and recurrent miscarriage: A systematic review and meta-analysis

机译：抗磷脂综合征和经常性误差：系统审查和荟萃分析

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Highlights ? Positive evidence of antiphospholipid syndrome and recurrent miscarriage. ? Association significant between antiphospholipid antibodies and recurrent miscarriage. ? High heterogeneity with limited bias in publications. ? There is lack of standardization between antiphospholipid antibodies tests. Abstract Antiphospholipid syndrome (APS) is an autoimmune condition that is associated with thrombosis and morbidity in pregnancy. The exact mechanisms by which these associations occur appear to be heterogeneous and are not yet well understood. The aim of this study was to identify and analyze publications in recent years to better understand the diagnosis and its contribution to monitoring APS among women with recurrent miscarriage (RM). This systematic review and meta-analysis was conducted using the PubMed and Web of Knowledge databases, with articles published between 2010 and 2014, according to the PRISMA statement. Of the 85 identified studies, nine were selected. Most of the studies reported an association between recurrent miscarriage and specific antiphospholipid antibodies, as anticardiolipin antibodies (aCL), lupus anticoagulant (LA), anti-β2-glycoprotein I antibodies (aβ2GPI) and antiphosphatidylserine (aPS), which showed a relationship with RM. The main result of the meta-analysis revealed association between antiphospholipid antibodies (aPLs) and/or APS compared to the patients with RM (OR: 0.279; 95% CI: 0.212-0.366) and APS cases compared to the patients with RM (OR: 0.083; 95% CI: 0.036-0.189). High heterogeneity among these studies (I 2 =100.0%, p
机译：强调 ？抗磷脂综合征和复发流产的阳性证据。还抗磷脂抗体和反复流产之间的显着显着。还在出版物中具有有限的偏倚异质性。还抗磷脂抗体试验缺乏标准化。摘要抗磷脂综合征（APS）是一种与妊娠中血栓形成和发病率相关的自身免疫病症。这些关联发生的确切机制似乎是异质的，并且尚不清楚。本研究的目的是近年来识别和分析出版物，以更好地了解诊断及其对具有复发流产（RM）的妇女的监测AP的贡献。根据PRISMA陈述，使用知识数据库的PubMed和Web和网络网络进行了系统审查和荟萃分析，并在2010年和2014年之间发表了文章。在85项确定的研究中，选择了九个。大多数研究报告了复发性流产和特定抗磷脂抗体之间的关联，如抗真生素抗体（ACL），狼疮抗凝血剂（LA），抗β2-糖蛋白I抗体（Aβ2GPI）和抗磷脂酰丝氨酸（APS），其显示与RM的关系。荟萃分析的主要结果显示与RM（或：0.279; 95％CI：0.212-0.366）和APS病例相比，抗磷脂抗体（APLS）和/或APS之间的关联与RM（或：0.083; 95％CI：0.036-0.189）。这些研究中的高异质性（I 2 = 100.0％，p

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