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首页> 外文期刊>Journal of spectroscopy >Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model
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Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model

机译：小动物模型中乳腺癌化疗治疗纵向拉曼光谱观察皮肤生化变化

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摘要

The cancer field effect (CFE) has been highlighted as one of indirect indications for tissue variations that are insensitive to conventional diagnostic techniques. In this research, we had a hypothesis that chemotherapy for breast cancer would affect skin biochemical compositions that would be reflected by Raman spectral changes. We used a fiber-optic probe-based Raman spectroscopy to perform preliminary animal experiments to validate the hypothesis. Firstly, we verified the probing depth of the fiber-optic probe (~800?μm) using a simple intravenous fat emulsion-filled phantom having a silicon wafer at the bottom inside a cuvette. Then, we obtained Raman spectra during breast cancer treatment by chemotherapy from a small animal model in longitudinal manner. Our results showed that the treatment causes variations of biochemical compositions in the skin. For further validation, the Raman spectra will have to be collected from more populations and spectra will need to be compared with immunohistochemistry of the breast tissue.
机译：癌症场效应（CFE）被突出显示为对常规诊断技术不敏感的组织变异的间接指示之一。在这项研究中，我们有一个假设，即乳腺癌的化疗会影响皮肤生化组合物，这些组合物将被拉曼光谱变化反射。我们使用光纤探针的拉曼光谱，进行初步动物实验以验证假设。首先，我们使用在比色皿内部的底部具有硅晶片的简单静脉内脂肪乳液填充的虚线验证了光纤探针（〜800μm）的探测深度。然后，我们通过在纵向的小动物模型中通过化疗在乳腺癌治疗过程中获得拉曼光谱。我们的研究结果表明，治疗导致皮肤中生化组合物的变化。为了进一步验证，必须从更多种群中收集拉曼光谱，并且需要与乳腺组织的免疫组织化学进行比较。

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