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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Risk of Stroke in 28,000 Patients with Celiac Disease: A Nationwide Cohort Study in Sweden
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Risk of Stroke in 28,000 Patients with Celiac Disease: A Nationwide Cohort Study in Sweden

机译：28,000名腹腔疾病患者中风的风险：瑞典的全国范围内的队列研究

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Background: Earlier studies on stroke in celiac disease (CD) have been underpowered, but a recent study suggested that childhood CD is associated with a 10-fold increased risk of death from stroke, although it was based on small numbers. We examined the risk of stroke in patients with biopsy-verified CD. Methods: We collected biopsy data from all 28 pathology departments in Sweden and identified 28,676 individuals with CD diagnosed between 1969 and 2007 (Marsh 3: villous atrophy). In the main analyses, we used Cox regression to estimate hazard ratios (HRs) for stroke in patients with CD compared with HRs for stroke in 141,806 sex- and age-matched controls. Results: During follow-up, there were 785 first-stroke diagnoses in patients with CD and 2937 in reference individuals. Patients with CD were at increased risk of stroke (HR 1.10; 95% confidence interval [CI] 1.01-1.19). HRs were similar for ischemic stroke and brain hemorrhage and were not affected by adjustment for type 1 diabetes, rheumatoid arthritis, use of medication against hypertension, or dyslipidemia. The absolute risk of stroke in patients with CD was 267 per 100,000 person-years (excess risk 24/100,000). The highest risk estimates occurred in the first year, with virtually no increased risk after more than 5 years of follow-up after CD diagnosis. The HR for stroke in childhood CD was 1.10 (95% CI 0.37-3.22). Conclusions: Patients with CD are at only a small increased risk of stroke, which persists only for a brief period after diagnosis. CD does not seem to be a major risk factor for stroke.
机译：背景：腹腔疾病（CD）的早期研究已经受到动力，但最近的一项研究表明，儿童CD与中风的死亡风险增加10倍，尽管它是基于少数。我们检查了活组织检查验证的CD患者中风的风险。方法：我们从瑞典的所有28个病理部门收集了活检数据，并在1969年至2007年间诊断了28,676名患有CD（Marsh 3：绒毛萎缩）。在主要分析中，我们使用CD患者中风的COX回归来估计脑卒中的危险比（HRS）与141,806岁的性别和年龄匹配的对照中的中风。结果：在随访期间，CD和2937患者中有785名初级脑卒中诊断。 CD患者患有卒中风险增加（HR 1.10; 95％置信区间[CI] 1.01-1.19）。 HRS类似于缺血性卒中和脑出血，不受调整的1型糖尿病，类风湿性关节炎，药物对高血压或血脂血症的影响。 CD患者中风的绝对风险为每10万人患者267人（24 / 100,000的过度风险）。最高风险估计在第一年发生，在CD诊断后5年以上的5年后几乎没有增加风险。儿童CD中风的HR为1.10（95％CI 0.37-3.22）。结论：CD患者患者患有卒中风险较小，仅在诊断后的短暂期间持续存在。 CD似乎并不是中风的主要危险因素。

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