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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Assessment of Carotid Plaque Inflammation in Diabetic and Nondiabetic Patients-An Exploratory Ultrasmall Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging Study
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Assessment of Carotid Plaque Inflammation in Diabetic and Nondiabetic Patients-An Exploratory Ultrasmall Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging Study

机译：糖尿病患者颈动脉斑块炎症的评估 - 探索性超顺磁性氧化铁增强磁共振成像研究

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Background: Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance (MR) imaging enables the identification of inflammation within the atheroma, predominantly by USPIO uptake by macrophages present in atherosclerotic tissue. Diabetic patients, however, may have dysfunctional macrophage activity, which may affect utilization of USPIO in identifying plaque inflammation in this patient cohort. Methods: Fifteen diabetic and fifteen nondiabetic patients underwent USPIO-enhanced carotid MR imaging using 1.5T MR system. Pre-and post-USPIO carotid MR images were manually coregistered. The percentage decrease in the signal intensity after USPIO administration was calculated as a relative measure of the USPIO uptake. Results: Diabetic and nondiabetic patients had comparable demographics and comorbidities. The mean global, maximum quadrant, and maximum slice changes showing change in relative signal intensity as a result of USPIO administration were comparable for the two patient cohorts (P > .05). Conclusions: USPIO can identify inflammatory burden with carotid atheroma in both diabetic and nondiabetic patients.
机译：背景：超级连锁氧化铁（USPIO） - 抗磁共振（MR）成像能够鉴定动脉瘤内的炎症，主要是通过动脉粥样硬化组织中存在的巨噬细胞的USPIO吸收。然而，糖尿病患者可能具有功能失调的巨噬细胞活性，这可能影响USPIO在鉴定该患者队列中的斑块炎症。方法：十五糖尿病和十五名非奶糖患者使用1.5T MR系统进行USPIO-增强的颈动脉MR成像。预先和Uspio CarotID MR图像手动进行内核。使用USPIO管理后的信号强度的百分比降低作为USPIO吸收的相对测量。结果：糖尿病和非糖尿病患者具有可比人口统计和合并症。由于USPIO给药而显示出相对信号强度的变化的平均全局，最大象限和最大切片变化与两名患者队列（P> .05）相当。结论：USPIO可以在糖尿病和非糖尿病患者中鉴定患有颈动脉动脉瘤的炎症负担。

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