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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >The Association Between Leukoaraiosis and Poor Outcome in Intracerebral Hemorrhage Is Not Mediated by Hematoma Growth
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The Association Between Leukoaraiosis and Poor Outcome in Intracerebral Hemorrhage Is Not Mediated by Hematoma Growth

机译：血清腺炎与脑出血中差的结合不受血肿生长介导的

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Background: The significance of white matter lesions (WMLs) in intracerebral hemorrhage (ICH) remains unclear. We investigated the effects of WML on initial hematoma volume, hematoma growth, intraventricular extension, and clinical outcome in patients with spontaneous ICH. Methods: Computed tomography scans of 262 patients included in a placebo arm of a prospective, multicenter trial were used for a semi-quantitative analysis of white matter changes. A logistic regression analysis was used to explore the effects on hematoma volume, volume changes, intraventricular hemorrhage, and clinical outcome after 90 days. Results: The degree of WML was not associated with initial hematoma volume, absolute and relative hematoma growth, hematoma growth > 33% or > 6 mL, or with intraventricular extension. WML significantly increased the odds for poor outcome after 90 days (adjusted OR 1.4, 95% CI 1.1-1.8, P =.02). Conclusions: WMLs were not associated with initial hematoma volume, hematoma growth, or intraventricular extension. WMLs were associated with poor outcome independently.
机译：背景：白质病变（WM1）在脑出血（ICH）中的意义仍然不清楚。我们研究了WML对自发ICH患者初始血肿体积，血肿生长，脑室内延伸和临床结果的影响。方法：计算的262名患者的计算机断层扫描扫描，包括在预处理的安慰剂组中，多中心试验中的患者用于白质变化的半定量分析。使用逻辑回归分析用于探讨血肿体积，体积变化，脑室出血和90天后临床结果的影响。结果：WML的程度与初始血肿体积，绝对和相对血肿生长，血肿生长> 33％或> 6mL，或具有脑内延伸。在90天后（调整或1.4,95％CI 1.1-1.8，P = .02），WML显着增加了较差结果的差异。结论：WMLs与初始血肿体积，血肿生长或脑室内延伸无关。 WMLS与独立的差异相关联。

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