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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Remote Limb Ischemic Conditioning during Cerebral Ischemia Reduces Infarct Size through Enhanced Collateral Circulation in Murine Focal Cerebral Ischemia
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Remote Limb Ischemic Conditioning during Cerebral Ischemia Reduces Infarct Size through Enhanced Collateral Circulation in Murine Focal Cerebral Ischemia

机译：脑缺血过程中远程肢体缺血调节通过鼠局灶性脑缺血的增强抵押循环来减少梗塞大小

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摘要

Background: Remote ischemic conditioning (RIC) induces protection in focal cerebral ischemia. The conditioning is divided into pre-, per-, and postconditioning. However, the mechanisms of RIC remain unknown. Objectives: This study aimed to determine the most effective subtype of RIC. We also examined involvement of collateral circulation on RIC. Methods: Transient middle cerebral artery occlusion (MCAO) was performed with nylon sutures in adult C57BL/6 mice under the monitoring of cerebral blood flow (CBF). Fifty mice were divided into 5 groups: MCAO control group, delayed pre-RIC group (RIC 24 hours before MCAO), early pre-RIC group (RIC 5 minutes before MCAO), per-RIC group (RIC during MCAO), and post-RIC group (RIC 5 minutes after MCAO). In other middle cerebral artery (MCA) control and per-RIC groups, collateral circulation was visualized with latex compound perfusion. Results: After MCAO, CBF was reduced by 80% in all groups. At the end of MCAO, relative increase in CBF in per-RIC group was significantly greater than that in MCA control, whereas the infarct volume in per-RIC group was significantly smaller than that in other groups. The diameter of leptomeningeal anastomosis was larger in the per-RIC group than that in the control group. Conclusions: Among the 4 RIC procedures, only the per-RIC group showed clear brain protection. Enhancement of collateral circulation could play a role in the protective effect of per-RIC.
机译：背景：远程缺血调理（RIC）在局灶性脑缺血中诱导保护。调节分为预先，每个和后处理。然而，RIC的机制仍然是未知的。目的：本研究旨在确定RIC最有效的亚型。我们还审查了抵押品循环对RIC的参与。方法：在脑血流（CBF）监测下，在成人C57BL / 6小鼠中用尼龙缝合线进行瞬时中脑动脉闭塞（MCAO）。将50只小鼠分为5组：MCAO对照组，延迟RIC次数（MCAO前24小时），早期预先血清群（MCAO前5分钟），PER-RIC基团（MCAO期间RIC），并发布 - 批量（MCAO后5分钟）。在其他中脑动脉（MCA）控制和每RIC组中，用乳胶复合灌注来观察侧支循环。结果：MCAO后，所有组中CBF减少了80％。在MCAO结束时，每次RIC组中CBF的相对升高显着大于MCA控制中的CBF，而每RIC组的梗塞体积显着小于其他组。百分之肌吻合术的直径在每次RIC组中比对照组更大。结论：在4条核查程序中，只有每权利集团才显示出明显的脑保护。抵押品循环的增强可以在每次RIC的保护作用中发挥作用。

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