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首页> 外文期刊>Journal of the advanced practitioner in oncology >Understanding and Managing Immune-Related Adverse Events Associated With Immune Checkpoint Inhibitors in Patients With Advanced Melanoma
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Understanding and Managing Immune-Related Adverse Events Associated With Immune Checkpoint Inhibitors in Patients With Advanced Melanoma

机译：理解和管理与晚期黑素瘤患者免疫检查点抑制剂相关的免疫相关不良事件

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摘要

The immune checkpoint inhibitors ipilimumab, nivolumab, and pem-brolizumab represent a substantial improvement in treating advanced melanoma but are associated with adverse events (AEs) likely related to general immunologic enhancement. To ensure that patients receive optimal benefit from these agents, prompt assessment and treatment of AEs are essential. We review the efficacy and safety profiles of these immune checkpoint inhibitors and describe guidelines for managing immune-related AEs. We also present case studies describing the management of toxicities in patients receiving immune checkpoint inhibitor therapy. These cases illustrate the importance of collecting a detailed medical history when administering immunotherapy, as this information is necessary to establish baseline, inform monitoring, and determine the etiology of symptoms. Advanced practice nurses and physician assistants are uniquely positioned to educate patients on the early recognition of AEs and have an important role in establishing appropriate monitoring and open dialogue among services.
机译：免疫检查点抑制剂Ipilimumab，Nivolumab和Pem-Brolizumab代表了治疗先进的黑色素瘤的显着改善，但与通用免疫学增强有关的不良事件（AES）有关。为了确保患者从这些药剂获得最佳益处，对AES的迅速评估和治疗至关重要。我们审查了这些免疫检查点抑制剂的疗效和安全谱，并描述了管理免疫相关AES的指导。我们还存在案例研究，描述接受免疫检查点抑制剂治疗的患者毒性的管理。这些病例说明了在施用免疫疗法时收集详细病史的重要性，因为这些信息是建立基线的必要条件，通知监测和确定症状的病因。先进的练习护士和医生助理是独特的，以教育患者在早期认识到AES，并在制定适当的监测和开放对话方面具有重要作用。

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