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首页> 外文期刊>Journal of the advanced practitioner in oncology >Osimertinib: A Novel Therapeutic Option for Overcoming T790M Mutations in Non-Small Cell Lung Cancer
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Osimertinib: A Novel Therapeutic Option for Overcoming T790M Mutations in Non-Small Cell Lung Cancer

机译:Osimertinib:一种新的治疗方法,用于克服非小细胞肺癌中的T790M突变

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摘要

Lung cancer is the leading cause of cancer death for men and women in the United States. A total of 224,390 new cases of lung cancer and 158,080 deaths were estimated to have occurred in 2016. Furthermore, one in four deaths due to cancer is expected to be from lung cancer (Siegel, Miller, & Jemal, 2016). Despite this high morbidity and mortality, tremendous advancements have been made in the treatment of lung cancer with the use of novel targeted therapies (Johnson, Schiller, & Bunn, 2014). Non-small cell lung cancer (NSCLC) accounts for 85% to 90% of all primary lung cancers, and a significant proportion of patients present with metastatic disease at diagnosis (Reck et al., 2014). Several genetic aberrations for the histologic subtype adenocarcinoma have been identified and are known to increase tumorigenesis and early carcinogen-esis; therefore, molecular profiling of tumor samples is now considered to be the standard of care (Siegelin & Borczuk, 2014).
机译:肺癌是美国男女癌症死亡原因。 估计2016年共有224,390例新的肺癌和158,080人死亡案例。此外,预计癌症引起的四种死亡人数是来自肺癌(Siegel,Miller,&Jemal,2016)。 尽管发病率和死亡率高,但在使用新型有针对性的疗法(Johnson,Schiller,&Bunn,2014)中,已经在治疗肺癌的巨大进步。 非小细胞肺癌(NSCLC)占所有原发性肺癌的85%至90%,并且诊断中存在转移性疾病的大部分患者(Reck等,2014)。 已经鉴定了几种用于组织学亚型腺癌腺癌的遗传像差,并已知增加肿瘤引发和早期致癌物质; 因此,肿瘤样品的分子分析现在被认为是护理标准(Siegelin&Borczuk,2014)。

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