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首页> 外文期刊>Journal of the International Association of Providers of AIDS Care. >HIV-Associated Toxic Epidermal Necrolysis at San Francisco General Hospital: A 13-Year Retrospective Review
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HIV-Associated Toxic Epidermal Necrolysis at San Francisco General Hospital: A 13-Year Retrospective Review

机译:艾滋病毒相关的毒性表皮病变旧金山综合医院:13年的回顾性审查

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Objectives: We sought to characterize recent cases of toxic epidermal necrolysis (TEN) in HIV-infected patients at San Francisco General Hospital (SFGH), a large HIV referral center. Methods: This was a retrospective analysis of HIV-infected patients diagnosed with TEN from January 2001 to May 2014 at SFGH. Results: Ten cases of TEN were identified, 50% of which occurred in HIV-infected individuals. Among the HIV-associated cases, causative agents were trimethoprim-sulfamethoxazole (TMP-SMX; n = 2), atovaquone, clindamycin, and fluconazole. No antiretroviral agents were implicated. Conclusion: Although limited by small sample size, our experience is reflective of the well-recognized increased incidence of TEN in HIV-positive patients and suggests that antimicrobial agents, particularly TMP-SMX, are the most common causative agents in this population. As 3 of the 5 HIV-associated TEN cases were caused by potentially inappropriate or unnecessary use of antibiotics, our experience highlights the importance of judicious use of systemic medications in populations susceptible to severe adverse drug reactions.
机译:目的:我们试图在旧金山综合医院(SFGH),艾滋病毒转诊中心近期感染艾滋病毒感染患者中的近期有毒表皮死亡病例(十)。方法:这是从2001年1月至2014年5月诊断患有艾滋病毒感染患者的回顾性分析。结果:鉴定了十个十例,其中50%发生在艾滋病毒感染的个体中。在艾滋病毒相关的病例中,致病剂是甲基硫磺酸甲氧唑(TMP-SMX; n = 2),Atovaquone,Clindamycin和氟康唑。没有涉及抗逆转录病毒剂。结论:虽然采用小型样品规模的限制,但我们的经验是反映艾滋病毒阳性患者的良好公认的发病率,并表明抗微生物剂,特别是TMP-SMX是该人群中最常见的致病药剂。由于5个艾滋病毒相关的十个病例中的3例是由潜在的不适当或不必要的抗生素使用引起的,我们的经验突出了可明智地利用系统药物在易受严重不良药物反应的群体中的重要性。

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