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首页> 外文期刊>Journal of the Medical Association of Thailand =: Chotmaihet thangphaet >Implication of pneumococcal conjugate vaccines to public health: Thailand perspective.
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Implication of pneumococcal conjugate vaccines to public health: Thailand perspective.

机译：肺炎球菌缀合物疫苗对公共卫生的影响：泰国观点。

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摘要

The pneumococcal conjugate vaccines (PCVs) have demonstrated good safety profile and efficacy against invasive pneumococcal diseases (IPD) caused by the serotypes included in the vaccines. The PCV also benefit to the unvaccinated children and adults from herd immunity. With the widespread use of the vaccine, emerging of non vaccine serotypes has been documented. The IPD burden in Thailand was found to be lower than that found in the western countries but the data in high risk population has been lacking. The PCV has been available in Thailand since 2006 as an optional vaccine, out of National Vaccine Program, with the uptake of less than 5% in children under 5 years of age. The serotypes distribution in Thailand has not changed significantly. In the year 2000-2005, compared with year 2006-2009, the most common serotypes in children < 5 years have been similar; comprising of 6B, 23F, 14, and 19F, however 19A has become more prevalence (6.2%) in the years 2006-2009. With the new breakpoint of penicillin susceptibility for non-meningeal strains, most penumococcal isolates in Thailand were susceptible to penicillin. To project the benefit for widespread use of PCV in Thailand the cost benefit analyses including the different types of PCV, the various dosing schedule, the benefit from herd immunity and the disadvantage of serotype replacement are needed.
机译：肺炎球菌缀合物疫苗（PCVs）已经证明了良好的安全性曲线和针对由疫苗中包含的血清型引起的侵袭性肺炎球菌疾病（IPD）的功效。 PCV还有利于来自畜群免疫的未接种催乳儿童和成年人。随着疫苗的广泛使用，已经记录了非疫苗血清型的出现。发现泰国的IPD负担低于西方国家的IPD负担，但高风险人口数据缺乏。自2006年以来，PCV已在泰国提供，作为一个可选的疫苗，避免国家疫苗计划，5岁以下儿童的摄取不到5％。泰国的血清型分布并没有显着变化。 2000 - 2005年，与2006 - 2009年相比，儿童最常见的血清型<5年来相似;然而，在6B，23F，14和19F中包含，19A年在2006 - 2009年中变得更普遍（6.2％）。随着对非脑膜菌株的青霉素易感性的新断点，泰国的大多数Penumococal分离物易患青霉素。为了将泰国PCV广泛使用的福利，需要不同类型的PCV，各种计量时间表，畜群免疫力以及血清型替代的缺点的成本效益分析。

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