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首页> 外文期刊>Journal of the Indian Chemical Society >Non-aqueous potentiometric determination of drugs mefenamic acid and paracetamol-mefenamic acid in single and double component pharmaceuticals
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Non-aqueous potentiometric determination of drugs mefenamic acid and paracetamol-mefenamic acid in single and double component pharmaceuticals

机译：单组分和双组分药物中药物梅芬酸和扑热氨酸 - 梅芬酸的非含水电位测定

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摘要

The non-aqueous potentiometric determination of drugs mefenamic acid and paracetamol-mefenamic acid has been worked out. These drugs are widely used in medicines either as a single component or in combination of two. The effect of solvent and concentration on determination of drug mefenamic acid along with its determination in single component tablets and paracetamol containing double component tablets has been studied using the solvent isopropanol and titrant KOH in isopropanol. The acidic drugs paracetamol-mefenamic acid were simultaneously determined in double component tablets by differentiating potentiometric titrations. Titrations were carried out using a pair of glass and saturated calomel electrodes. This method was found to be quite simple, efficient, precise and convenient for assay of single and double component tablets. The results obtained are comparable to those obtained by Indian Pharmacopoeia (IP) method.
机译：已经制定了非含水电位测定药物培苯胺酸和扑热氨酸 - 梅氨酸酸。 这些药物广泛用于药物中作为单一组分或两种组合。 已经使用溶剂异丙醇和异丙醇滴定剂在异丙醇中研究了溶剂和含有双组分片中的单一组分片中和旁向酰胺醇的测定的溶剂对药物培苯胺酸的影响。 通过区分电位滴定，在双组分片中同时测定酸性药物甲基酰胺 - 梅芬酸。 使用一对玻璃和饱和的Calomel电极进行滴定。 发现该方法非常简单，高效，精确，方便的单组分片和双组分片进行测定。 得到的结果与印度药典（IP）方法获得的结果相当。

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