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首页> 外文期刊>Journal of Veterinary Research >Effects of tiletamine-xylazine-tramadol combination and its specific antagonist on AMPK in the brain of rats
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Effects of tiletamine-xylazine-tramadol combination and its specific antagonist on AMPK in the brain of rats

机译：钛胺 - 木嗪 - 曲马多组合及其特异性拮抗剂对大鼠脑中的AMPK的影响

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摘要

Introduction: Tiletamine-xylazine-tramadol (XFM) has few side effects and can provide good sedation and analgesia. Adenosine 5'-monophosphate-activated protein kinase (AMPK) can attenuate trigeminal neuralgia. The study aimed to investigate the effects of XFM and its specific antagonist on AMPK in different regions of the brain. Material and Methods: A model of XFM in the rat was established. A total of 72 Sprague Dawley (SD) rats were randomly divided into three equally sized groups: XFM anaesthesia (M group), antagonist (W group), and XFM with antagonist interactive groups (MW group). Eighteen SD rats were in the control group and were injected intraperitoneally with saline (C group). The rats were sacrificed and the cerebral cortex, cerebellum, hippocampus, thalamus, and brain stem were immediately separated, in order to detect AMPK alpha mRNA expression by quantitative PCR. Results: XFM was able to increase the mRNA expression of AMPK alpha 1 and AMPK alpha 2 in all brain regions, and the antagonist caused the opposite effect, although the effects of XFM could not be completely reversed in some areas. Conclusion: XFM can influence the expression of AMPK in the central nervous system of the rat, which can provide a reference for the future development of anaesthetics for animals.
机译：简介：钛胺 - 木嗪 - 曲马多（XFM）副作用很少，可提供良好的镇静和镇痛。腺苷5'-单磷酸活化的蛋白激酶（AMPK）可以衰减三叉神经痛。该研究旨在探讨XFM及其特定拮抗剂对大脑不同地区AMPK的影响。材料和方法：建立了大鼠XFM模型。将72只Sprague Dawley（SD）大鼠随机分为三个等大小的组：XFM麻醉（M组），拮抗剂（W组）和XFM，拮抗剂相互作用（MW组）。 18只SD大鼠在对照组中，用盐水（C组）腹膜内注射。处死大鼠，立即分离大鼠脑皮层，小脑，海马，丘脑和脑干，以便通过定量PCR检测AMPKαmRNA表达。结果：XFM能够在所有脑区中增加AMPKα1和AMPKα2的mRNA表达，并且拮抗剂导致相反的效果，尽管XFM的影响在某些区域中不能完全逆转。结论：XFM可以影响大鼠中枢神经系统中AMPK的表达，可以为动物麻醉剂的未来发展提供参考。

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  • 来源
    《Journal of Veterinary Research》 |2019年第2期|共8页
  • 作者

    Ma Ning; Li Xin; Wang Hong-bin; Gao Li; Xiao Jian-hua;

  • 作者单位

    Northeast Agr Univ Key Lab Prov Educ Dept Heilongjiang Common Anim Dis Preve Coll Vet Med Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Key Lab Prov Educ Dept Heilongjiang Common Anim Dis Preve Coll Vet Med Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Key Lab Prov Educ Dept Heilongjiang Common Anim Dis Preve Coll Vet Med Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Key Lab Prov Educ Dept Heilongjiang Common Anim Dis Preve Coll Vet Med Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Key Lab Prov Educ Dept Heilongjiang Common Anim Dis Preve Coll Vet Med Harbin 150030 Heilongjiang Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 动物医学（兽医学）;
  • 关键词

    brain; AMPK; xylazine; tramadol; tiletamine;

    机译：大脑;安培;甲嗪;曲马多;钛胺;

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