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首页> 外文期刊>Journal of Veterinary Research >Characterisation of thrombocytes in Osteichthyes
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Characterisation of thrombocytes in Osteichthyes

机译：骨粒细胞血栓细胞的表征

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摘要

Thrombocytes in vertebrates other than mammals, inter alia in fish, are analogues of platelets in mammals. In Osteichthyes, these cells take part in haemostatic processes, including aggregation and release reactions in cases of blood vessel damage, and in the immune response development as well. This paper discusses the development of thrombocytes in Osteichthyes, taking into account the need to make changes to the concept of grouping progenitor cells as suggested in the literature. The following pages present the morphological and cytochemical properties of thrombocytes as well as their defence functions, and also point out differences between thrombocytes in fish and platelets in mammals. The paper further highlights the level of thrombocytes' immune activity observed in fish and based on an increased proportion of these cells in response to antigenic stimulation, on morphological shifts towards forms characteristic of dendritic cells after antigenic stimulation and on the presence of surface structures and cytokines released through, inter alia, gene expression of TLR receptors, MHC class II protein-coding genes and pro-inflammatory cytokines. The study also points out the need to recognise thrombocytes in Osteichthyes as specialised immune cells conditioning non-specific immune mechanisms and playing an important role in affecting adaptive immune mechanisms.
机译：除哺乳动物之外的脊椎动物中的血小板血液中的血液中，尤其是鱼类，是哺乳动物中血小板的类似物。在骨质细胞中，这些细胞参与血管科病程，包括在血管损伤和免疫反应发育中的聚集和释放反应。本文讨论了骨质细胞血栓细胞的发展，考虑到在文献中提出的祖先细胞进行改变的必要性。以下页面呈现血小板和防御功能的形态学和细胞化学特性，并且还指出了哺乳动物中鱼和血小板中的血小板之间的差异。本文进一步突出了鱼类中观察到的血小板免疫活性的水平，并基于抗原刺激的这些细胞的比例增加，对抗原刺激后树突细胞的形式特征的形态转化，以及表面结构和细胞因子的存在除其他外，通过TLR受体的基因表达，MHC II类蛋白质编码基因和促炎细胞因子。该研究还指出，需要识别骨质细胞的血栓细胞，作为专门的免疫细胞调节非特异性免疫机制并在影响适应性免疫机制方面发挥重要作用。

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