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首页> 外文期刊>Journal of Veterinary Research >Effects of repeated lipopolysaccharide treatment on growth performance, immune organ index, and blood parameters of Sprague-Dawley rats
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Effects of repeated lipopolysaccharide treatment on growth performance, immune organ index, and blood parameters of Sprague-Dawley rats

机译：反复脂多糖治疗对Sprague-Dawley大鼠生长性能，免疫器官指标和血液参数的影响

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Introduction: The study was designed to investigate the effects of repeated lipopolysaccharide (LPS) treatment on growth performance, lymphoid organ indexes, and blood cells in Sprague-Dawley rats. Material and Methods: Forty healthy weaned Sprague-Dawley rats were randomly equally divided into LPS and control groups. Each rat in the LPS group was injected via the caudal vein with LPS (100 mu g/kg b.w.) for 10 days, and the control group was treated with an equal volume of normal saline. On the 1st, 4th , 7th , and 10th days, growth performance, lymphoid organ indexes, and blood cells were evaluated in five necropsied rats. Results: When rats were treated 3-10 times with LPS, their body weight and average daily gains increased more slowly than in the control group (P 0.05). Repeated LPS treatment significantly increased spleen weight and the ratio of spleen to body weight (P 0.05). White blood cells, neutrophils, and neutrophil percentage increased (P 0.05) remarkably, but lymphocyte percentage, haemoglobin, and blood platelet counts decreased significantly (P 0.05). Conclusion: LPS treatment obviously suppresses growth and promotes peripheral immune organ proliferation. It is indicated that host protective mechanism can be activated by multiple small doses of LPS and prevents organs from further damage during stress status.
机译：介绍：该研究旨在探讨反复脂多糖（LPS）治疗对Sprague-Dawley大鼠生长性能，淋巴器官指标和血细胞的影响。材料和方法：四十个健康的断奶型 - Dawley大鼠随机等于LPS和对照组。 LPS组中的每只大鼠通过尾部静脉注射LPS（100μg/ kg B.W.）10天，并用相等体积的甘盐处理对照组。在第1，第4，第7天和第10天，在五位尸检大鼠中评估了生长性能，淋巴室指标和血细胞。结果：当大鼠用LPS处理3-10次时，它们的体重和平均每日收益比对照组更缓慢地增加（P <0.05）。重复的LPS处理显着增加了脾脏重量和脾脏与体重的比例（P <0.05）。白细胞，中性粒细胞和中性粒细胞百分比增加（P <0.05）显着，但淋巴细胞百分比，血红蛋白和血小板计数显着降低（P <0.05）。结论：LPS治疗明显抑制生长并促进外周免疫器官增殖。结果表明，宿主保护机制可以通过多剂量的LPS激活，并防止器官在应力状态下从进一步的损坏。

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