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首页> 外文期刊>Journal of Veterinary Research >Major histocompatibility complex in Osteichthyes
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Major histocompatibility complex in Osteichthyes

机译：骨粒细胞主要组织相容性

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Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II molecules (MHC II-D) have been identified in Osteichthyes. In the latter lineage, three MHC II molecule sublineages have been identified (MHC II-A, -B and -E). As regards MHC class I molecules in Osteichthyes, it is important to take note of the fact that the lineages U and Z in MHC I genes have been identified in almost all fish species examined so far. Phylogenetic studies into MHC II molecule genes of sublineages A and B suggest that they may be descended from the genes of the sublineage named A/B that have been identified in spotted gar (Lepisosteus oculatus). The sublineage E genes of MHC II molecules, which represent the group of non-polymorphic genes with poor expression in the tissues connected with the immune system, are present in primitive fish, i.e. in paddlefish, sturgeons and spotted gar (Lepisosteus oculatus), as well as in cyprinids (Cyprinidae), Atlantic salmon (Salmo salar), and rainbow trout (Oncorhynchus mykiss). Full elucidation of the details relating to the organisation and functioning of the particular components of the major histocompatibility complex in Osteichthyes can advance the understanding of the evolution of the MHC molecule genes and the immune mechanism.
机译：基于可用基因组序列的分析，已经确定了MHC I类分子（MHC IU，-Z，-S，-L和-P）的五种基因谱系以及MHC II类分子（MHC II-D）的一种基因谱系在骨科。在后一种谱系中，已经鉴定了三种MHC II分子升华（MHC II-A，-B和-E）。关于骨质细胞中的MHC I类分子，重要的是注意到在迄今为止所检查的几乎所有鱼类中都鉴定了MHC I基因中的谱系U和Z。升华A和B的MHC II分子基因的系统发育研究表明，它们可以从被察觉的GAR（Lepisosteus Oculatus）中鉴定的Sublineage的基因中解除。 MHC II分子的Sublineage E分子的e基因，其代表与免疫系统连接的组织中表达不良的非多态基因组，以原始鱼类，即在桨鱼，梯形和斑点甘蓝（Lepisosteus Oculatus）中存在，如以及塞浦路替（钙喹啉），大西洋鲑鱼（沙摩酱）和彩虹鳟鱼（oncorhynchus mykiss）。全面阐明与骨质细胞主要组织相容性复合物的特定组分有关的细节和功能可以推进对MHC分子基因的演变和免疫机制的理解。

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