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首页> 外文期刊>Journal of women’s health >Sex as a Biological Variable: A 5-Year Progress Report and Call to Action
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Sex as a Biological Variable: A 5-Year Progress Report and Call to Action

机译：作为生物变量的性行为：5年的进度报告并致电行动

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A little over 5 years ago, the U.S. National Institutes of Health (NIH) announced the intention to develop policies to require applicants to report plans to balance male and female cells and animals in preclinical investigations. Soon thereafter, the NIH issued a request for information from the scientific community and consulted with various stakeholders. The feedback received was considered during development of policy requiring the consideration of sex as a biological variable (SABV) in NIH-funded research on vertebrate animals and humans, which went into effect for applications due on or after January 25, 2016. We identified NIH programs related to SABV and reviewed SABV-relevant scientific literature. We find that the application of SABV throughout the research process can serve as a guiding principle to improve the value of biomedical science. The NIH is engaged in ongoing efforts to develop resources to help investigators consider SABV in their research. We also provide an update on lessons learned, highlight ways that different disciplines consider SABV, and describe the opportunities for scientific discovery that applying SABV offers. We call on NIH's various stakeholders to redouble their efforts to integrate SABV throughout the biomedical research enterprise. Sex- and gender-aware investigations are critical to the conduct of rigorous and transparent science and the advancement of personalized medicine. This kind of research achieves its greatest potential when sex and gender considerations are integrated into the biomedical research enterprise in an end-to-end manner, from basic and preclinical investigations, through translational and clinical research, to improved health care delivery.
机译：美国国家卫生研究院（NIH）宣布有意制定政策，以便要求申请人报告计划在临床前调查中平衡男性和女性细胞和动物的计划。此后，NIH很快就向科学界发出了信息的请求，并与各种利益攸关方进行了咨询。在制定政策期间考虑了所收到的反馈，要求在NIH资助的脊椎动物和人类的NIH资助的研究中审议性行为（SABV），这对2016年1月25日或之后的申请生效。我们确定了NIH与SABV相关的计划，并审查了SABV相关的科学文献。我们发现SABV在整个研究过程中的应用可以作为提高生物医学科学价值的指导原则。 NIH从事正在进行的努力，开发资源，以帮助调查人员考虑SABV的研究。我们还提供了有关经验教训的更新，突出了不同学科考虑SABV的方式，并描述了应用SABV提供的科学发现的机会。我们呼吁NIH的各种利益相关者加倍努力整合整个生物医学研究企业的SABV。性别和性别意识的调查对于严谨和透明的科学和个性化医学的进步至关重要。这种研究实现了最大的潜力，当时性别和性别考虑因终以最终的方式纳入生物医学研究企业，通过基本和临床前调查，通过翻译和临床研究，改善医疗保健交付。

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