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首页> 外文期刊>Journal of the Association for Research in Otolaryngology: JARO >Three-dimensional architecture of hair-bundle linkages revealed by electron-microscopic tomography.
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Three-dimensional architecture of hair-bundle linkages revealed by electron-microscopic tomography.

机译：电子微观断层扫描显示的头发束连杆的三维架构。

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摘要

The senses of hearing and balance rest upon mechanoelectrical transduction by the hair bundles of hair cells in the inner ear. Located at the apical cellular surface, each hair bundle comprises several tens of stereocilia and a single kinocilium that are interconnected by extracellular proteinaceous links. Using electron-microscopic tomography of bullfrog saccular sensory epithelia, we examined the three-dimensional structures of basal links, kinociliary links, and tip links. We observed significant differences in the appearances and dimensions of these three structures and found two distinct populations of tip links suggestive of the involvement of different proteins, splice variants, or protein-protein interactions. We noted auxiliary links connecting the upper portions of tip links to the taller stereocilia. Tip links and auxiliary links show a tendency to adopt a globular conformation when disconnected from the membrane surface.
机译：在内耳中毛发束的机械电转导的听觉和平衡的感觉。 每个发束位于顶端蜂窝表面，每个发束包括几十个立体纤胺和单个磷油，其通过细胞外蛋白环节互连。 使用Bulbrog囊性感官上皮的电子 - 微观层析术，我们检查了基础链路，丝网链路和尖端链路的三维结构。 我们观察到这三种结构的外表和尺寸的显着差异，并发现了两个不同的尖端群，旨在提示不同蛋白质，剪接变体或蛋白质 - 蛋白质相互作用的累积。 我们注意到辅助链接将尖端链路的上部连接到更高的立体纤厘。 尖端链路和辅助链路显示出在与膜表面断开连接时采用球状构象的趋势。

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